Evidence map›Paper›PMID 35490898›Full record

ArticleJournal of molecular biology2022

Molecular Determinants of Human T-cell Leukemia Virus Type 1 Gag Targeting to the Plasma Membrane for Assembly.

Dominik Herrmann, Heather M Hanson, Lynne W Zhou, Rayna Addabbo, Nora A Willkomm, Isaac Angert, Joachim D Mueller, Louis M Mansky, Jamil S Saad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dominik HerrmannDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States.
Heather M HansonInstitute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, United States.
Lynne W ZhouDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States.
Rayna AddabboInstitute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, United States; School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, United States.
Nora A WillkommInstitute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, United States.
Isaac AngertInstitute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, United States; School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, United States.
Joachim D MuellerInstitute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, United States; School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, United States.
Louis M ManskyInstitute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, United States. Electronic address: mansky@umn.edu.
Jamil S SaadDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States. Electronic address: saad@uab.edu.
University of Minnesota · USUniversity of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Minnesota Craniofacial Research Training ProgramT90DE022732 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, KIM CARPENTER · 2012 to 2023
$4.9M
Minnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2M
HTLV-1 Particle Analysis and Gag InteractionsR01GM098550 · NIGMS · UNIVERSITY OF MINNESOTA · PI MANSKY, LOUIS M. · 2012 to 2020
$3.1M
Structural basis for HIV-1 Gag interactions with cellular and viral constituentsR01AI150901 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Terje Dokland · 2019 to 2026
$2.9M
MicroCal Auto-iTC200; automated high sensitivity isothermal titration calorimetryS10RR026478 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROUILLETTE, CHRISTIE G. · 2010 to 2010
$250k
Analysis of human retrovirus particle assembly sitesF30DE031829 · NIDCR · UNIVERSITY OF MINNESOTA · PI WILLKOMM, NORA · 2021 to 2024
$214k
Comparative human retroviral assembly in the context of cell polarizationF31AI147805 · NIAID · UNIVERSITY OF MINNESOTA · PI HANSON, HEATHER M · 2019 to 2022
$126k
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR026478NIAID NIH HHS F31 AI147805NIAID NIH HHS R01 AI150901NIAID NIH HHS T32 AI083196NIDCR NIH HHS F30 DE031829NIDCR NIH HHS T90 DE022732NIGMS NIH HHS R01 GM098550
6 · The paper itself

Abstract

Assembly of human T-cell leukemia virus type 1 (HTLV-1) particles is initiated by the trafficking of virally encoded Gag polyproteins to the inner leaflet of the plasma membrane (PM). Gag-PM interactions are mediated by the matrix (MA) domain, which contains a myristoyl group (myr) and a basic patch formed by lysine and arginine residues. For many retroviruses, Gag-PM interactions are mediated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Indexed as

Cell MembraneGene Products, gagHuman T-lymphotropic virus 1Virus AssemblyArginineHumansLysinePhosphatidylinositol 4,5-DiphosphatePhosphatidylserinesProtein BindingArginineGene Products, gagLysinePhosphatidylinositol 4,5-DiphosphatePhosphatidylserinesGag polyproteinhuman immunodeficiency virus type 1 (HIV-1)human T-cell leukemia virus type 1 (HTLV-1)matrix (MA) proteinplasma membrane (PM)

Identifiers

PMID35490898
PMCPMC10557380
OpenAlexW4225261466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.