Evidence map›Paper›PMID 35490727›Full record

ArticleJornal de pediatria

Rhinovirus as the main co-circulating virus during the COVID-19 pandemic in children.

Fernanda Hammes Varela, Ivaine Tais Sauthier Sartor, Márcia Polese-Bonatto, Thaís Raupp Azevedo, Luciane Beatriz Kern, Tiago Fazolo, Caroline Nespolo de David, Gabriela Oliveira Zavaglia, Ingrid Rodrigues Fernandes, João Ronaldo Mafalda Krauser and 2 more

Open access · goldAbstract read
In one paragraph

Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  10. Respiratory virus circulation during pandemic: Why were some viruses still circulating?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Review
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  14. Identification ofMolecules (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Fernanda Hammes VarelaSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Ivaine Tais Sauthier SartorSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Márcia Polese-BonattoSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Thaís Raupp AzevedoSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Luciane Beatriz KernSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Tiago FazoloUniversidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Caroline Nespolo de DavidSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Gabriela Oliveira ZavagliaSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Ingrid Rodrigues FernandesSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
João Ronaldo Mafalda KrauserSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Renato T SteinSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Marcelo Comerlato ScottaSocial Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: marcelo.scotta@hmv.org.br.
Hospital Moinhos de Vento · BRPontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChanges in the epidemiology of respiratory infections during the restrictions imposed as a response to the coronavirus disease 2019 (COVID-19) pandemic have been reported elsewhere. The present study's aim was to describe the prevalence of a large array of respiratory pathogens in symptomatic children and adolescents during the pandemic in Southern Brazil.

methodsHospitalized and outpatients aged 2 months to 18 years with signs and symptoms of acute COVID-19 were prospectively enrolled in the study from May to November 2020 in two hospitals in a large metropolitan area in a Brazilian city. All participants performed a real-time PCR panel assessing 20 respiratory pathogens (three bacteria and 17 viruses).

results436 participants were included, with 45 of these hospitalized. Rhinovirus was the most prevalent pathogen (216/436) followed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 97/436), with a coinfection of these two viruses occurring in 31/436 participants. The remaining pathogens were found in 24 symptomatic participants (adenovirus, n = 6; Chlamydophila pneumoniae, n = 1; coronavirus NL63, n = 2; human enterovirus, n = 7; human metapneumovirus, n = 2; Mycoplasma pneumoniae, n = 6). Hospitalization was more common among infants (p = 0.004) and those with pathogens other than SARS-CoV-2 (p = 0.001).

conclusionDuring the period of social distancing in response to COVID-19, the prevalence of most respiratory pathogens was unusually low. Rhinovirus remained as the main virus co-circulating with SARS-CoV-2. COVID-19 in symptomatic children was less associated with hospitalization than with other respiratory infections in children and adolescents.

Indexed as

CoinfectionCOVID-19Respiratory Tract InfectionsVirusesAdolescentChildHumansInfantPandemicsRhinovirusSARS-CoV-2CoinfectionCOVID-19RhinovirusSARS-CoV-2

Identifiers

PMID35490727
PMCPMC9015957
OpenAlexW4224225213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.