Evidence map›Paper›PMID 35490597›Full record

ArticleMedical image analysis2022

Predicting brain structural network using functional connectivity.

Lu Zhang, Li Wang, Dajiang Zhu, Alzheimer's Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in Medical image analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
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  6. Oblique Genomics Mixture of Experts: Prediction of Brain Disorder With Aging-Related Changes of Brain's Structural Connectivity Under Genomic Influences.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  7. A Unified Continuous Staging Framework for Alzheimer's Disease and Lewy Body Dementia via Hierarchical Anatomical Features.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  8. Article
  9. Article
  10. Review
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  12. INDIVIDUALIZED TRAJECTORY PREDICTION OF EARLY DEVELOPING FUNCTIONAL CONNECTIVITY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025
    Article
  13. Article
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  19. Contrastive Brain Network Learning via Hierarchical Signed Graph Pooling Model.IEEE transactions on neural networks and learning systems · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lu ZhangDepartment of Computer Science and Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA.
Li WangDepartment of Computer Science and Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA; Department of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Dajiang ZhuDepartment of Computer Science and Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA. Electronic address: dajiang.zhu@uta.edu.
Alzheimer's Disease Neuroimaging InitiativeDepartment of Computer Science and Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA.

Funding

Mapping Trajectories of Alzheimer's Progression via Personalized Brain Anchor-nodesR01AG075582 · NIA · UNIVERSITY OF TEXAS ARLINGTON · PI Gang Li, Dajiang Zhu · 2022 to 2026
$2.7M
NIA NIH HHS R01 AG075582
6 · The paper itself

Abstract

Uncovering the non-trivial brain structure-function relationship is fundamentally important for revealing organizational principles of human brain. However, it is challenging to infer a reliable relationship between individual brain structure and function, e.g., the relations between individual brain structural connectivity (SC) and functional connectivity (FC). Brain structure-function displays a distributed and heterogeneous pattern, that is, many functional relationships arise from non-overlapping sets of anatomical connections. This complex relation can be interwoven with widely existed individual structural and functional variations. Motivated by the advances of generative adversarial network (GAN) and graph convolutional network (GCN) in the deep learning field, in this work, we proposed a multi-GCN based GAN (MGCN-GAN) to infer individual SC based on corresponding FC by automatically learning the complex associations between individual brain structural and functional networks. The generator of MGCN-GAN is composed of multiple multi-layer GCNs which are designed to model complex indirect connections in brain network. The discriminator of MGCN-GAN is a single multi-layer GCN which aims to distinguish the predicted SC from real SC. To overcome the inherent unstable behavior of GAN, we designed a new structure-preserving (SP) loss function to guide the generator to learn the intrinsic SC patterns more effectively. Using Human Connectome Project (HCP) dataset and Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset as test beds, our MGCN-GAN model can generate reliable individual SC from FC. This result implies that there may exist a common regulation between specific brain structural and functional architectures across different individuals.

Indexed as

ConnectomeNeural Networks, ComputerBrainEye Diseases, HereditaryGenetic Diseases, X-LinkedHumansMagnetic Resonance ImagingNeuroimagingBrain connectivityGenerative adversarial networkGraph convolution networksStructure-function relationship

Identifiers

PMID35490597
PMCPMC9792121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.