Evidence map›Paper›PMID 35490510›Full record

Observational studyRespiratory medicine2022

Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infection.

Nicholas Russell Plummer, Andrew Fogarty, Dominick Shaw, Timothy Card, Joe West, Colin Crooks

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicholas Russell PlummerAdult Critical Care, Nottingham University Hospitals NHS Trust, NG7 2UH, UK. Electronic address: nickplummer@nhs.net.
Andrew FogartyNIHR Respiratory Biomedical Research Centre, University of Nottingham, NG7 2UH, UK.
Dominick ShawNIHR Respiratory Biomedical Research Centre, University of Nottingham, NG7 2UH, UK.
Timothy CardNottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, NG7 2UH, UK; Population and Lifespan Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, NG7 2UH, UK.
Joe WestPopulation and Lifespan Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, NG7 2UH, UK.
Colin CrooksNottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, NG7 2UH, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, NG7 2UH, UK.
Nottingham University Hospitals NHS Trust · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to assess whether asymptomatic ("happy") hypoxia was an identifiable physiological phenotype of COVID-19 acute respiratory distress syndrome (ARDS), and associated with need for ICU admission.

methodsWe performed an observational cohort study of all adult patients admitted with hypoxaemic respiratory failure to a large acute hospital Trust serving the East Midlands, UK. Patients with confirmed COVID-19 were compared to those without. Physiological response to hypoxaemia was modelled using a linear mixed effects model.

resultsOf 1,586 patients included, 75% tested positive for SARS-CoV-2. The ROX index was 2.08 min

conclusionsPatients with COVID-19 display a more symptomatic phenotype in response to hypoxaemia than those with other causes of hypoxaemic respiratory failure, however individual patients exhibit a wide range of responses. As such although asymptomatic hypoxaemia may be a phenomenon in any individual patient with hypoxaemic respiratory failure, it is no more frequently observed in those with SARS-CoV-2 infection than without.

Indexed as

COVID-19Respiratory Distress SyndromeRespiratory InsufficiencyHumansHypoxiaSARS-CoV-2ARDSClinical deteriorationCOVID-19Hypoxaemia

Identifiers

PMID35490510
PMCPMC9047547
OpenAlexW4225010660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.