Evidence map›Paper›PMID 35490167›Full record

ArticleScientific reports2022

Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C.

Nasim Shahidi Hamedani, Felix Lucian Happich, Eva-Maria Klein, Heiko Rühl, Günter Mayer, Johannes Oldenburg, Jens Müller, Bernd Pötzsch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nasim Shahidi Hamedani *Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany. Nasim.shahidi_hamedani@ukbonn.de.
Felix Lucian Happich *Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany.
Eva-Maria KleinInstitute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany.
Heiko RühlInstitute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany.
Günter MayerLife and Medical Sciences Institute, University of Bonn, 53115, Bonn, Germany.
Johannes OldenburgInstitute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany.
Jens MüllerInstitute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany.
Bernd PötzschInstitute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, 53127, Bonn, Germany.
University Hospital Bonn · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activated protein C (APC) is a serine protease with anticoagulant and cytoprotective activities which make it an attractive target for diagnostic and therapeutic applications. In this work, we present one-step activation of APC from a commercial source of protein C (PC, Ceprotin) followed by rapid and efficient purification using an APC-specific aptamer, HS02-52G, loaded on MyOne superparamagnetic beads. Due to the Ca

Indexed as

AnticoagulantsProtein CBlood Coagulation TestsMagnetic Iron Oxide NanoparticlesOligonucleotidesAnticoagulantsOligonucleotidesProtein C

Identifiers

PMID35490167
PMCPMC9056527
OpenAlexW4225271922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.