ArticleJournal of exposure science & environmental epidemiology2023
Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.
Article in Journal of exposure science & environmental epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of maternal exposure to trace elements and toxic metals with repeated measurements of foetal and early-childhood growth: a systematic review.Occupational and environmental medicine · 2025Pooled it
- Maternal mineral nutrition during early pregnancy and neonatal growth: findings from a China birth cohort study.Frontiers in nutrition · 2026Article
- Prevalence of Exposure to Environmental Metal Mixtures Among Pregnant Women in the United States National Health and Nutrition Examination Survey (NHANES) 1999-2018.Journal of xenobiotics · 2025Article
- Interactive effects between lead-cadmium co-exposure and VEGFA gene polymorphisms on renal dysfunction: a gene-environment interaction study.Frontiers in public health · 2025Article
- A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother-child birth (ELitE) cohort from Central India.Frontiers in public health · 2025Article
- Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth.Maternal & child nutrition · 2024Article
- Strain-level characterization of health-associated bacterial consortia that colonize the human gut during infancy.medRxiv : the preprint server for health sciences · 2023Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundThere has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth.
objectiveWe evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs.
methodsUrinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored.
resultsIncreased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC. SIGNIFICANCE: We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth. IMPACT: We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.
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