Evidence map›Paper›PMID 35490031›Full record

ArticleTrends in genetics : TIG2022

Catastrophic DNA replication in unscheduled tetraploid cells.

Gwenola Manic, Lorenzo Galluzzi, Ilio Vitale

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in genetics : TIG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Surviving the Storm: The Role of Poly- and Depolyploidization in Tissues and Tumors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  3. Polyploidy and mTOR signaling: a possible molecular link.Cell communication and signaling : CCS · 2024
    Review
  4. Review
  5. Giant cells: multiple cells unite to survive.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Gwenola ManicItalian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy. Electronic address: gwenola.manic@gmail.com.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.
Ilio VitaleItalian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy. Electronic address: iliovit@gmail.com.
Italian institute for Genomic Medicine · ITCornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G

Indexed as

DNA ReplicationTetraploidyAneuploidyCell Cycle ProteinsHumansMitosisS PhaseCell Cycle Proteinscell cycle checkpointchromosomal instabilitymitotic spindleregulated cell deathreplication stress

Identifiers

PMID35490031
OpenAlexW4224990482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.