Evidence map›Paper›PMID 35489360›Full record

ReviewLancet (London, England)2022

What can work and how? An overview of evidence-based interventions and delivery strategies to support health and human development from before conception to 20 years.

Tyler Vaivada, Zohra S Lassi, Omar Irfan, Rehana A Salam, Jai K Das, Christina Oh, Bianca Carducci, Reena P Jain, Daina Als, Naeha Sharma and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Lancet (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Clinical practice guideline "preconception care".Archives of gynecology and obstetrics · 2026
    Guideline
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  4. Pooled it
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  12. Article
  13. Review
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  16. Exploring exclusive breastfeeding readiness: experiences of first-time mothers in Lusaka, Zambia.International journal of qualitative studies on health and well-being · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Tyler VaivadaCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Zohra S LassiRobinson Research Institute and Adelaide Medical School, the University of Adelaide, SA, Australia; Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Omar IrfanCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Rehana A SalamDivision of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Jai K DasDivision of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Christina OhCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Bianca CarducciCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Reena P JainCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Daina AlsCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Naeha SharmaCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Emily C KeatsCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
George C PattonCentre for Adolescent Health, Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
Margaret E KrukDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Boston, MA, USA.
Robert E BlackInstitute for International Programs, Johns Hopkins Bloomberg School of Public Health, Baltimore, Johns Hopkins University, MD, USA.
Zulfiqar A BhuttaCenter for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada; Centre of Excellence in Women and Child Health and Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan. Electronic address: zulfiqar.bhutta@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progress has been made globally in improving the coverage of key maternal, newborn, and early childhood interventions in low-income and middle-income countries, which has contributed to a decrease in child mortality and morbidity. However, inequities remain, and many children and adolescents are still not covered by life-saving and nurturing care interventions, despite their relatively low costs and high cost-effectiveness. This Series paper builds on a large body of work from the past two decades on evidence-based interventions and packages of care for survival, strategies for delivery, and platforms to reach the most vulnerable. We review the current evidence base on the effectiveness of a variety of essential and emerging interventions that can be delivered from before conception until age 20 years to help children and adolescents not only survive into adulthood, but also to grow and develop optimally, support their wellbeing, and help them reach their full developmental potential. Although scaling up evidence-based interventions in children younger than 5 years might have the greatest effect on reducing child mortality rates, we highlight interventions and evidence gaps for school-age children (5-9 years) and the transition from childhood to adolescence (10-19 years), including interventions to support mental health and positive development, and address unintentional injuries, neglected tropical diseases, and non-communicable diseases.

Indexed as

Child MortalityDelivery of Health CareAdolescentAdultChildChild, PreschoolEvidence-Based MedicineHumansInfant, NewbornMorbidityPovertyYoung Adult

Identifiers

PMID35489360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.