Evidence map›Paper›PMID 35488811›Full record

ReviewEuropean journal of heart failure2022

Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology.

Alberto Aimo, Giuseppe Vergaro, Arantxa González, Andrea Barison, Josep Lupón, Victoria Delgado, A Mark Richards, Rudolf A de Boer, Thomas Thum, Henrike Arfsten and 41 more

Erratum issuedOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Formation of ICell metabolism · 2025
    Article
  10. 2024 update in heart failure.ESC heart failure · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
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  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

51 authors at 20 institutions in 26 countries.

Alberto AimoScuola Superiore Sant'Anna, Pisa, Italy.
Giuseppe VergaroScuola Superiore Sant'Anna, Pisa, Italy.
Arantxa GonzálezCIMA Universidad de Navarra, and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Andrea BarisonScuola Superiore Sant'Anna, Pisa, Italy.
Josep LupónInstitut del Cor, Hospital Universitari Germans Trias i Pujol Badalona, Barcelona, Spain.
Victoria DelgadoInstitut del Cor, Hospital Universitari Germans Trias i Pujol Badalona, Barcelona, Spain.
A Mark RichardsUniversity of Otago, Dunedin, New Zealand.
Rudolf A de BoerDepartment of Cardiology, University Medical Centre Groningen, Groningen, The Netherlands.
Thomas ThumClinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Henrike ArfstenClinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Martin HülsmannClinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Inês Falcao-PiresFaculty of Medicine, University of Porto, Porto, Portugal.
Javier DíezCenter for Applied Medical Research, Pamplona, Spain.
Roger S Y FooDepartment of Medicine, Yong Loo-Lin School of Medicine, National University Hospital, Singapore, Singapore.
Mark Yan Yee ChanDepartment of Medicine, Yong Loo-Lin School of Medicine, National University Hospital, Singapore, Singapore.
Chukwuemeka G Anene-NzeluDepartment of Medicine, Yong Loo-Lin School of Medicine, National University Hospital, Singapore, Singapore.
Magdy AbdelhamidFaculty of Medicine, Cairo University, Cairo, Egypt.
Stamatis Adamopoulos2nd Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Athens, Greece.
Stefan D AnkerDepartment of Cardiology (CVK), and Berlin Institute of Health Center for Regenerative Therapy (BCRT), German Center for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Berlin, Germany.
Yuri BelenkovLomonosv Moscow State University, Moscow, Russia.
Tuvia Ben GalCardiology Department, Rabin Medical Center, Beilinson, Israel.
Alain Cohen-SolalHospital Lariboisière, Paris, France.
Michael BöhmUniversity of the Saarland, Homburg/Saar, Germany.
Ovidiu ChioncelEmergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu' Bucharest, University of Medicine Carol Davila, Bucharest, Romania.
Ewa A JankowskaInstitute of Heart Disases, Wroclaw Medical University, Wroclaw, Poland.
Finn GustafssonHeart Centre, Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark.
Loreena HillQueen's University Belfast, Belfast, UK.
Tiny JaarsmaLinkoping University, Linkoping, Sweden.
James L JanuzziMassachusetts General Hospital and Baim Institute for Clinical Research, Boston, MA, USA.
Pardeep JhundUniversity of Glasgow, Glasgow, UK.
Yuri LopatinVolgograd State Medical University, Volgograd, Russia.
Lars H LundDepartment of Medicine, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Marco MetraCardiology, ASST Spedali Civili; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Davor MilicicUniversity of Zagreb School of Medicine, Zagreb, Croatia.
Brenda MouraFaculty of Medicine, University of Porto, Porto, Portugal.
Christian MuellerDepartment of Cardiology, University Hospital, Basel, Switzerland.
Wilfried MullensHospital Oost-Limburg, Genk, Belgium.
Julio NúñezHospital Clínico Universitario de Valencia, INCLIVA, Universidad de Valencia, Valencia, Spain.
Massimo F PiepoliCardiology Division, Castelsangiovanni Hospital, Castelsangiovanni, Italy.
Amina RakishevaScientific Research Institute of Cardiology and Internal Medicine, Almaty, Kazakhstan.
Arsen D RistićDepartment of Cardiology, University Clinical Center of Serbia, Belgrade, Serbia.
Patrick RossignolUniversité de Lorraine, Centre d'Investigations Cliniques-Plurithématique 1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Gianluigi SavareseDepartment of Medicine, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Carlo G TocchettiCardio-Oncology Unit, Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.
Sophie van LinthoutBerlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
Maurizio VolterraniIRCCS San Raffaele, Rome, Italy.
Petar SeferovicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Giuseppe RosanoSt. George's Hospitals, NHS Trust, University of London, London, UK.
Andrew J S CoatsUniversity of Warwick, Coventry, UK.
Michele EmdinScuola Superiore Sant'Anna, Pisa, Italy.
Antoni Bayes-GenisCIBERCV, Carlos III Institute of Health, Madrid, Spain.
Fondazione Toscana Gabriele Monasterio · ITHospital Universitari Germans Trias i Pujol · ESKarolinska University Hospital · SEMedical University of Vienna · ATNational University of Singapore · SGScuola Superiore Sant'Anna · ITUniversidade do Porto · PTUniversity of Belgrade · RSAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBaim Institute for Clinical Research · USBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DECairo University · EGCarol Davila University of Medicine and Pharmacy · ROCentro de Investigación en Red en Enfermedades Cardiovasculares · ESCharité - Universitätsmedizin Berlin · DEChartered Institute of Management Accountants · GBCopenhagen University Hospital · DKFederico II University Hospital · ITFrench Clinical Research Infrastructure Network · FRGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with heart failure with reduced ejection fraction because most studies on cardiac remodelling focused on this setting.

Indexed as

CardiologyHeart FailureBiomarkersHumansStroke VolumeVentricular Function, LeftVentricular RemodelingBiomarkersBiomarkersEjection fractionHeart failureImagingPredictorsRemodellingTherapies

Identifiers

PMID35488811
OpenAlexW4225121800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.