Evidence map›Paper›PMID 35488784›Full record

ArticleJournal of cardiac surgery2022

Extracorporeal membrane oxygenation for respiratory failure in phases of COVID-19 variants.

Emily Shih, J Michael DiMaio, John J Squiers, Arundhati Rao, Gelareh Rahimighazikalayeh, Talia C Meidan, Kara A Monday, Britton Blough, Dan Meyer, Gary S Schwartz and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiac surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Emily ShihDepartment of General Surgery, Baylor University Medical Center, Dallas, Texas, USA.ORCID http://orcid.org/0000-0002-2426-513X
J Michael DiMaioDepartment of Cardiothoracic Surgery, Baylor Scott and White The Heart Hospitals, Plano, Texas, USA.
John J SquiersDepartment of General Surgery, Baylor University Medical Center, Dallas, Texas, USA.
Arundhati RaoDepartment of Pathology, Baylor Scott and White Temple, Temple, Texas, USA.
Gelareh RahimighazikalayehBaylor Scott and White Research Institute, Dallas, Texas, USA.
Talia C MeidanBaylor Scott and White Research Institute, Dallas, Texas, USA.
Kara A MondayDepartment of General Surgery, Baylor University Medical Center, Dallas, Texas, USA.
Britton BloughDepartment of General Surgery, Baylor University Medical Center, Dallas, Texas, USA.
Dan MeyerDepartment of Cardiothoracic Surgery, Baylor University Medical Center, Dallas, Texas, USA.
Gary S SchwartzDepartment of Cardiothoracic Surgery, Baylor University Medical Center, Dallas, Texas, USA.
Timothy J GeorgeDepartment of Cardiothoracic Surgery, Baylor Scott and White The Heart Hospitals, Plano, Texas, USA.
Baylor University Medical Center · USBaylor Medical Center at Garland · USBaylor Scott & White Medical Center - Temple · US

Funding

Philanthropic gift from Satish and Yasmin Gupta to Baylor Scott & White The Heart Hospital, Plano
6 · The paper itself

Abstract

backgroundAdaptive mutations of the severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) virus have emerged throughout the coronavirus disease 2019 (COVID-19) pandemic. The characterization of outcomes in patients requiring extracorporeal membrane oxygenation (ECMO) for severe respiratory distress from COVID-19 during the peak prevalence of different variants is not well known.

methodsThere were 131 patients with laboratory-confirmed SARS-CoV-2 infection supported by ECMO at two referral centers within a large healthcare system. Three predominant variant phase time windows (Pre-Alpha, Alpha, and Delta) were determined by a change-point analyzer based on random population sampling and viral genome sequencing. Patient demographics and outcomes were compared.

resultsThe average age of patients was 46.9 ± 10.5 years and 70.2% (92/131) were male. Patients cannulated for ECMO during the Delta variant wave were younger compared to earlier Pre-Alpha (39.3 ± 7.8 vs. 48.0 ± 11.1 years) and Alpha phases (39.3 ± 7.8 vs. 47.2 ± 7.7 years) (p < .01). The predominantly affected race in the Pre-Alpha phase was Hispanic (52.2%; 47/90), while in Alpha (61.5%; 16/26) and Delta (40%; 6/15) variant waves, most patients were White (p < .01). Most patients received a tracheostomy (82.4%; 108/131) with a trend toward early intervention in later phases compared to Pre-Alpha (p < .01). There was no significant difference between the duration of ECMO, mechanical support, intensive care unit (ICU) length of stay (LOS), or hospital LOS over the three variant phases. The in-hospital mortality was overall 41.5% (54/131) and was also similar. Six-month survival of patients who survived to discharge was 92.2% (71/77).

conclusionsThere was no significant difference in survival or time on ECMO support in patients during the peak prevalence of the three variants.

Indexed as

COVID-19Extracorporeal Membrane OxygenationRespiratory InsufficiencyAdultFemaleHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2acute respiratory distress syndrome, extracorporeal membrane oxygenationcirculatory support

Identifiers

PMID35488784
PMCPMC9348093
OpenAlexW4225133811

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.