ArticleJournal of veterinary internal medicine2022
Relationship between histological tumor margins and magnetic resonance imaging signal intensities in brain neoplasia of dogs.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- The Definitive-Intent 10-Fraction Radiotherapy Protocol ('The Zurich Protocol') Yields Lasting Tumour Control and Survival in Dogs With Intracranial Meningiomas.Veterinary and comparative oncology · 2026Article
- Magnetic resonance imaging of primary central nervous system neoplasms of dogs and cats: Basic concepts for diagnostic pathologists.Veterinary pathology · 2026Review
- Neurologic improvement and tumor shrinkage after radiotherapy in dogs with imaging-based intracranial neoplasia.Journal of veterinary internal medicine · 2026Article
- An Illustrated Scoping Review of the Magnetic Resonance Imaging Characteristics of Canine and Feline Brain Tumors.Animals : an open access journal from MDPI · 2024Article
- Anaplastic oligodendroglioma with nasal invasion and systemic metastasis in a dog.The Journal of veterinary medical science · 2023Article
- Quantitative analysis of magnetic resonance images for characterization of blood-brain barrier dysfunction in dogs with brain tumors.Journal of veterinary internal medicine · 2023Article
- Chemotherapy for the treatment of intracranial glioma in dogs.Frontiers in veterinary science · 2023Review
- Relationship between histological tumor margins and magnetic resonance imaging signal intensities in brain neoplasia of dogs.Journal of veterinary internal medicine · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial neoplasia is relatively common in dogs and stereotactic radiotherapy, surgical debulking, or both, are the most successful treatment approaches. A key component of treatment planning involves delineating tumor margin on magnetic resonance imaging (MRI) examinations. How MRI signal intensity alterations relate to histological tumor margins is unknown.
objectivesDirectly compare histological brain sections to MRI sequence images and determine which sequence alteration best correlates with tumor margins. ANIMALS: Five dogs with glioma, 4 dogs with histiocytic sarcoma, and 3 dogs with meningioma.
methodsRetrospective cohort study. Histological brain sections were registered to in vivo MRI scan images obtained within 7 days of necropsy. Margins of signal intensity alterations (T2-weighted, fluid-attenuating inversion recovery [FLAIR], T1-weighted and contrast enhancement) were compared directly to solid tumor and surgical margins identified on histology. Jacquard similarity metrics (JSM) and cross-sectional areas were calculated.
resultsIn glioma cases, margins drawn around T2-weighted hyperintensity were most similar to surgical margins (JSM, 0.66 ± 0.17) when compared to other sequences. In both meningioma (JSM, 0.57 ± 0.21) and histiocytic sarcoma (JSM, 0.75 ± 0.11) margins of contrast enhancement were most similar to surgical margins. CONCLUSIONS AND CLINICAL IMPORTANCE: Signal intensities correspond to tumor margins for different tumor types and facilitate surgical and radiation therapy planning using MRI images.
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