ReviewHead & neck2022
Laryngotracheal stenosis: Mechanistic review.
Review in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for the Management of Adult Subglottic and Tracheal Stenosis From the Korean Bronchoesophagological Society.Clinical and experimental otorhinolaryngology · 2026Guideline
- Comparative success of different graft types in pediatric laryngotracheal reconstruction: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Evaluation and Comparison of Treatment with Polymerised Collagen or Pirfenidone as Stand-Alone Therapy on the Production of Profibrotic Factors in Tracheal Stenosis and Tracheal Anastomosis Scarring After Resection.International journal of molecular sciences · 2026Article
- Intubated COVID-19 Patients More Likely to Develop Subglottic Stenosis.Laryngoscope investigative otolaryngology · 2026Article
- M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis.Clinical and translational medicine · 2026Article
- Animal models of benign airway stenosis: Advances in construction techniques, evaluation systems, and perspectives.Animal models and experimental medicine · 2026Review
- Mechanism of SLC15A3 Regulating Macrophage Oxidative Stress in the Pathogenesis of Traumatic Tracheal Stenosis.Journal of inflammation research · 2026Article
- Integrating single-cell and bulk RNA-Seq to unravel the molecular mechanisms of airway stenosis.Functional & integrative genomics · 2025Article
- Benign subglottic stenosis from a rheumatologist' perspective: a narrative review.Clinical rheumatology · 2025Review
- Stent and Resection Anastomosis in Patients with Complex Tracheal Stenosis: The Stars Retrospective Multicenter Trial.Interdisciplinary cardiovascular and thoracic surgery · 2025Observational
- circRNA-associated-ceRNA networks in patients with traumatic tracheal stenosis.Scientific reports · 2025Article
- Association between anxiety and depression and sleep quality in benign laryngotracheal stenosis patients and analysis of risk factors.World journal of psychiatry · 2025Article
- Factors affecting the development of recurrence in patients who underwent tracheal resection due to tracheal stenosis.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Management and outcomes of acquired benign tracheoesophageal fistula: a single-centre experience of 58 cases.Journal of thoracic disease · 2025Article
- 5-Aminolevulinic acid-mediated photodynamic therapy improves scar healing of laryngeal wounds in rats.Lasers in medical science · 2025Article
- Review
- Article
- Can Epirubicin Be Used in Laryngology Practice Like Mitomycin? An Experimental and Pioneering Study.Iranian journal of otorhinolaryngology · 2025Article
- Laryngotracheal stenosis: a single-center retrospective analysis of endoscopic treatment strategies and recurrence.Annals of medicine and surgery (2012) · 2024Article
- An Ovine Model Yields Histology and Gene Expression Changes Consistent with Laryngotracheal Stenosis.The Laryngoscope · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this review article is to summarize the existing literature surrounding wound healing mechanisms in laryngotracheal stenosis.
methodsA review of general wound healing pathophysiology, followed by a focused review of iatrogenic laryngotracheal stenosis (iLTS) and idiopathic subglottic stenosis (iSGS) as conditions of aberrant wound healing.
resultsiLTS is the scarring of the laryngotracheal complex, coming secondary to injury from prolonged intubation. iSGS is a chronic fibroinflammatory scarring and narrowing of the subglottic airway in the absence of any obvious preceding injury or trauma. They are both thought to result from a prolonged and dysregulated wound healing response that promotes the deposition of pathologic scar in the airway.
conclusionsUnderstanding the mechanisms that underlie wound healing will help identify and intervene on the process early in its development and discover future therapies that target individual wound healing mechanisms limiting the incidence of this recalcitrant disease process.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.