ArticleClinical pharmacology and therapeutics2022
Opportunities and Challenges for Decentralized Clinical Trials: European Regulators' Perspective.
Article in Clinical pharmacology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Application of deep learning technology in breast cancer: a systematic review of segmentation, detection, and classification approaches.Biomedical engineering online · 2026Pooled it
- Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study.BMJ (Clinical research ed.) · 2025Pooled it
- Next-Generation Cognitive-Behavioral Therapy for Depression: Integrating Digital Tools, Teletherapy, and Personalization for Enhanced Mental Health Outcomes.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Recommendations to promote equity, diversity and inclusion in decentralized clinical trials.Nature medicine · 2024Guideline
- Feasibility of Decentralised Response-Guided Albuminuria Monitoring to Optimise Empagliflozin and Finerenone Therapy in Type 2 Diabetes and Chronic Kidney Disease.Diabetes, obesity & metabolism · 2026Trial
- Lactiplantibacillus plantarum Lp815 improves sleep and increases urinary GABA in a randomized, double-blind, placebo-controlled study of sleep disturbance.Scientific reports · 2026Trial
- A Real-Life Digital Intervention for Personalized Nutrition in Adults With Overweight or Obesity: Remote Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Integrating Personal Health Records to Improve Data Integrity in Trials With Decentralized Elements: A Pilot Study.Clinical and translational science · 2025Trial
- Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms.Clinical and translational science · 2023Trial
- FlowSpot Enables Decentralized Phenotypic and Functional Cellular Immune Profiling from Dried Blood Spots.bioRxiv : the preprint server for biology · 2026Article
- Addressing the Key Challenges of Decentralized Clinical Trials in Europe: Multistakeholder Perspective Delphi Study.Journal of medical Internet research · 2026Article
- Do remote clinical trials offer carbon savings while maintaining research quality? Experiences from the Eczema Bathing Study.Skin health and disease · 2026Article
- Implementation of decentralized clinical trials in Korea from a resource-based perspective.Translational and clinical pharmacology · 2026Article
- Ethical Challenges and Considerations in Decentralized Clinical Trials (DCTs): Insights from a Scoping Review.Therapeutic innovation & regulatory science · 2026Article
- An at-home blood collection device for remote immune monitoring by high-parameter flow cytometry.JCI insight · 2026Article
- The potential of artificial intelligence in clinical trials.European journal of clinical investigation · 2026Review
- Decentralized clinical trials in cardiovascular disease : A primer for clinical trialists.Nature cardiovascular research · 2026Review
- SWOT analysis of decentralised clinical trials from an ethical, legal, regulatory and operational perspective.BMC medical ethics · 2026Article
- Implementing Teletrials to Improve Equity of Access for Regional Patients With Cancer: Report From the Victorian Teletrial Collaborative.Asia-Pacific journal of clinical oncology · 2026Article
- Research on the road: Partnering with community emergency medical services to expand access to clinical trials.Journal of clinical and translational science · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decentralized clinical trials (DCTs) have the potential to improve accessibility, diversity, and retention in clinical trials by moving trial activities to participants' homes and local surroundings. In this study, we conducted semi-structured interviews with 20 European regulators to identify regulatory challenges and opportunities for the implementation of DCTs in the European Union. The key opportunities for DCTs that were recognized by regulators include a reduced participation burden, which could facilitate the participation of underserved patients. In addition, regulators indicated that data collected in DCTs are expected to be more representative of the real world. Key challenges recognized by regulators for DCTs include concerns regarding investigator oversight and participants' safety when physical examinations and face-to-face contact are limited. To facilitate future learning, hybrid clinical trials with both on-site and decentralized elements are proposed by the respondents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.