Evidence map›Paper›PMID 35488460›Full record

ArticleBirth defects research2022

Distance from home to birth hospital, transfer, and mortality in neonates with hypoplastic left heart syndrome in California.

Neha J Purkey, Chen Ma, Henry C Lee, Susan R Hintz, Gary M Shaw, Doff B McElhinney, Suzan L Carmichael

Open access · greenAbstract read
In one paragraph

Article in Birth defects research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Neha J PurkeyDivision of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-8054-0098
Chen MaDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Henry C LeeDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Susan R HintzDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Gary M ShawDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-7438-4914
Doff B McElhinneyDivision of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Suzan L CarmichaelDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Stanford Medicine · US

Funding

California Center of BD-STEPS - Finding Causes and Preventives of Birth DefectsU01DD001033 · DD · STANFORD UNIVERSITY · PI CARMICHAEL, SUZAN L, SHAW, GARY M · 2013 to 2017
$3.4M
Disparities in Care, Morbidity & Survival Among Infants with Birth DefectsR01MD007796 · NIMHD · STANFORD UNIVERSITY · PI CARMICHAEL, SUZAN L · 2014 to 2017
$1.6M
NCBDD CDC HHS U01 DD001033NCBDD CDC HHS U01 DD001226NIMHD NIH HHS R01 MD007796
6 · The paper itself

Abstract

backgroundPrior studies report a lower risk of mortality among neonates with hypoplastic left heart syndrome (HLHS) who are born at a cardiac surgical center, but many neonates with HLHS are born elsewhere and transferred for repair. We investigated the associations between the distance from maternal home to birth hospital, the need for transfer after birth, sociodemographic factors, and mortality in infants with HLHS in California from 2006 to 2011.

methodsWe used linked data from two statewide databases to identify neonates for this study. Three groups were included in the analysis: "lived close/not transferred," "lived close/transferred," and "lived far/not transferred." We defined "lived close" versus "lived far" as 11 miles, the median distance from maternal residence to birth hospital. Log-binomial regression models were used to identify the association between sociodemographic variables, distance to birth hospital and transfer. Cox proportional hazards models were used to identify the association between mortality and distance to birth hospital and transfer. Models were adjusted for sociodemographic variables.

resultsInfants in the lived close/not transferred and the lived close/transferred groups (vs. the lived far/not transferred group) were more likely to live in census tracts above the 75th percentile for poverty with relative risks 1.94 (95% confidence interval [CI] 1.41-2.68) and 1.21 (95% CI 1.05-1.40), respectively. Neonatal mortality was higher among the lived close/not transferred group compared with the lived far/not transferred group (hazard ratio 1.77, 95% CI 1.17-2.67).

conclusionsInfants born to mothers experiencing poverty were more likely to be born close to home. Infants with HLHS who were born close to home and not transferred to a cardiac center had a higher risk of neonatal mortality than infants who were delivered far from home and not transferred. Future studies should identify the barriers to delivery at a cardiac center for mothers experiencing poverty.

Indexed as

Hypoplastic Left Heart SyndromeDatabases, FactualHospitalsHumansInfantInfant MortalityInfant, NewbornProportional Hazards Modelsbirth hospitalcongenital heart diseasehypoplastic left heart syndromemortalityneonatesocial determinants of health

Identifiers

PMID35488460
PMCPMC9288528
OpenAlexW4225255202

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.