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ArticleEuropean archives of psychiatry and clinical neuroscience2022

Association between aerobic fitness and the functional connectome in patients with schizophrenia.

Lukas Roell, Isabel Maurus, Daniel Keeser, Temmuz Karali, Boris Papazov, Alkomiet Hasan, Andrea Schmitt, Irina Papazova, Moritz Lembeck, Dusan Hirjak and 16 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03466112 (Aerobic Exercise for the Improvement of Cognition and Enhancement of Recovery in Post-acute Schizophrenia), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03466112 nacompletednot on this map

Aerobic Exercise for the Improvement of Cognition and Enhancement of Recovery in Post-acute Schizophrenia

TypeinterventionalSponsorLudwig-Maximilians - University of MunichRan2016 to 2021Enrolled180ConditionsSchizophreniaArmsendurance training, balance and tone program
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Physical exercise therapy in schizophrenia spectrum disorders: current evidence and treatment recommendations.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lukas RoellDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany. Lukas.Roell@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-0284-2290
Isabel MaurusDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Daniel KeeserDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Temmuz KaraliDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Boris PapazovDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Alkomiet HasanDepartment of Psychiatry and Psychosomatics of the University Augsburg, Bezirkskrankenhaus Augsburg, University of Augsburg, Augsburg, Germany.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Irina PapazovaDepartment of Psychiatry and Psychosomatics of the University Augsburg, Bezirkskrankenhaus Augsburg, University of Augsburg, Augsburg, Germany.
Moritz LembeckDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Dusan HirjakCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Eliska SykorovaCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Cristina E ThiemeCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Susanne MuenzDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Valentina SeitzDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
David GreskaDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Mattia CampanaDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Elias WagnerDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Lisa LoehrsDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Sophia StoeckleinDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Birgit Ertl-WagnerDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Johannes PoemslDepartment of Psychiatry and Psychotherapy, Medical Faculty, Technical University of Munich, University Hospital 'Klinikum Rechts Der Isar', Munich, Germany.
Astrid RoehDepartment of Psychiatry and Psychosomatics of the University Augsburg, Bezirkskrankenhaus Augsburg, University of Augsburg, Augsburg, Germany.
Berend MalchowDepartment of Psychiatry and Psychotherapy, University Hospital Göttingen, Göttingen, Germany.
Katriona Keller-VaradyHannover Medical School, Institute of Sports Medicine, Hannover, Germany.
Andreas Meyer-LindenbergCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.

Funding

Bundesministerium für Bildung und Forschung 01EE1407E
6 · The paper itself

Abstract

backgroundSchizophrenia is accompanied by widespread alterations in static functional connectivity associated with symptom severity and cognitive deficits. Improvements in aerobic fitness have been demonstrated to ameliorate symptomatology and cognition in people with schizophrenia, but the intermediary role of macroscale connectivity patterns remains unknown.

objectiveTherefore, we aim to explore the relation between aerobic fitness and the functional connectome in individuals with schizophrenia. Further, we investigate clinical and cognitive relevance of the identified fitness-connectivity links.

methodsPatients diagnosed with schizophrenia were included in this cross-sectional resting-state fMRI analysis. Multilevel Bayesian partial correlations between aerobic fitness and functional connections across the whole brain as well as between static functional connectivity patterns and clinical and cognitive outcome were performed. Preliminary causal inferences were enabled based on mediation analyses.

resultsStatic functional connectivity between the subcortical nuclei and the cerebellum as well as between temporal seeds mediated the attenuating relation between aerobic fitness and total symptom severity. Functional connections between cerebellar seeds affected the positive link between aerobic fitness and global cognition, while the functional interplay between central and limbic seeds drove the beneficial association between aerobic fitness and emotion recognition.

conclusionThe current study provides first insights into the interactions between aerobic fitness, the functional connectome and clinical and cognitive outcome in people with schizophrenia, but causal interpretations are preliminary. Further interventional aerobic exercise studies are needed to replicate the current findings and to enable conclusive causal inferences.

trial registrationThe study which the manuscript is based on is registered in the International Clinical Trials Database (ClinicalTrials.gov identifier [NCT number]: NCT03466112) and in the German Clinical Trials Register (DRKS-ID: DRKS00009804).

Indexed as

ConnectomeSchizophreniaBayes TheoremBrainCross-Sectional StudiesExerciseHumansMagnetic Resonance ImagingExerciseFitnessfMRIFunctional connectivityNeuroimagingSchizophrenia

Identifiers

PMID35488054
PMCPMC9508005

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.