ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2022
Visit-To-Visit Blood Pressure Variability and Subthreshold Depressive Symptoms in Older Adults.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Blood Pressure Variability and Cognitive Decline: A Post Hoc Analysis of the SPRINT MIND Trial.American journal of hypertension · 2023Trial
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- Review
- Cross-sectional and longitudinal functional network alterations associated with subthreshold depressive symptoms in healthy older adults.Frontiers in aging neuroscience · 2026Article
- Association Between Short-Term Blood Pressure Variability and the Alzheimer's Disease Continuum.Brain and behavior · 2025Article
- Article
- Short-Term Blood Pressure Variability among Young Adults at High or Low Risk for Depression.Journal of clinical medicine · 2024Article
- Relationship between visit-to-visit blood pressure variability and depressive mood in Korean primary care patients.BMC primary care · 2024Article
- Association of white matter hyperintensities and clinical vascular burden with depressive symptoms in Black older adults.International journal of geriatric psychiatry · 2024Article
- Age-Specific Association Between Visit-to-Visit Blood Pressure Variability and Hearing Loss: A Population-Based Cohort Study.Innovation in aging · 2024Article
- Under pressure: A systematic review of the association between blood pressure variability with depression and anxiety.Cerebral circulation - cognition and behavior · 2024Article
- Higher metabolic variability increases the risk of depressive disorder in type 2 diabetes mellitus: a longitudinal nationwide cohort study.Frontiers in psychiatry · 2023Article
- Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein ɛ4 Carriers versus Apolipoprotein ɛ3 Homozygotes.Journal of Alzheimer's disease : JAD · 2023Article
- Prevalence and risk factors for depression and anxiety in patients with nasolacrimal duct obstruction.Frontiers in psychiatry · 2023Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesDepression is related to increased risk for dementia, possibly through links with cerebrovascular disease. Blood pressure variability is an emerging risk factor for cerebrovascular disease and dementia, but relationships with affective symptoms remain understudied.
designRetrospective analysis of prospective cohort study.
settingAlzheimer's Disease Neuroimaging Initiative.
participants505 older adults without history of dementia or recent depression underwent three to four blood pressure measurements over 12 months and completed a self-report measure of depressive symptoms (Geriatric Depression Scale - 15 Item) at study baseline and 24-months follow-up. MEASUREMENTS: Blood pressure variability was calculated as variability independent of mean and maximum minus minimum. Regression models investigated relationships between blood pressure variability and severity of self-reported depressive symptoms at 24-months follow-up after controlling for several variables, including average blood pressure, antihypertensive use, antidepressant use, and baseline depressive symptom severity.
resultsElevated diastolic blood pressure variability was related to greater total depressive symptom score at follow-up (ß = .16 [95% CI 0.02, .30]; p = 0.03), with specific contribution from increased severity of symptoms of dysphoria (odds ratio = 1.35 [95% CI 1.07, 1.75]; p = 0.02). Blood pressure variability was not significantly related to other symptom subscales, including those reflecting life satisfaction or withdrawal.
conclusionsFindings suggest that elevated diastolic blood pressure variability is related to subthreshold depressive symptomatology in older adults without history of dementia or recent depression, independent of average blood pressure. Blood pressure variability may be an understudied vascular risk factor linked with depression and cognitive impairment, with potential therapeutic implications.
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