SynthesisThe European respiratory journal2022
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- The association between early-life respiratory infections and childhood asthma: a meta-analytic perspective.Frontiers in medicine · 2026Pooled it
- Early exposure to infections increases the risk of allergic rhinitis-a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- Early predictors of persistent childhood asthma and allergic rhinitis: A machine learning study using post-hoc explainability.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Rhinovirus Species in Acute Respiratory Tract Infections and the Risk of Asthma in Children.Pediatric pulmonology · 2026Article
- Impaired CC16-mediated host responses to rhinovirus in nasal epithelial cells from patients with asthma.The Journal of allergy and clinical immunology · 2026Article
- Allergy burden score and lung function impairment in children with asthma: a dose-response cross-sectional study.European journal of pediatrics · 2026Article
- Treatable traits of small airway dysfunction in children with asthma and advances in small airway-targeted therapeutic research: a narrative review.Translational pediatrics · 2026Review
- Longitudinal Study of Subsequent Wheezing/Asthma Risk Among Children Hospitalized for Acute Respiratory Infections - Yichang City, Hubei Province, China, 2017-2024.China CDC weekly · 2026Article
- Epidemiological characteristics of six respiratory pathogens in respiratory infections in Fuzhou, China.Respiratory research · 2026Article
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- The role of the early-life gut microbiome in childhood asthma.Gut microbes · 2025Review
- Global to local burden and inequalty of low respiratory infections among children and adolescents across 953 locations.BMC public health · 2025Article
- Multimodal-based auxiliary diagnosis for pediatric community acquired pneumonia.Scientific reports · 2025Article
- Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma.The journal of allergy and clinical immunology. Global · 2025Article
- Independent and interactive effects of viral species on early-life lower respiratory tract illness.The Journal of infection · 2025Article
- Maternal Folic Acid Supplementation, Perinatal Factors, and Pre-Adolescent Asthma: Findings from the Healthy Growth Study.Nutrients · 2025Article
- Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study.medRxiv : the preprint server for health sciences · 2025Article
- Postnatal antibiotic exposure due to maternal group B streptococcus is associated with childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Effect of COVID-19 Disease on Serum Vitamin D Status in Children with Asthma-A Retrospective Study.Journal of clinical medicine · 2025Article
- Incidence and predictors of respiratory tract infections among birth cohorts in Ethiopia, 2023.Italian journal of pediatrics · 2025Article
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Authors and funding
69 authors at 20 institutions in 18 countries.
Evelien R van MeelThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Sara M Mensink-BoutThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-5381-6287
Herman T den DekkerThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Tarunveer S AhluwaliaCOPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Isabella Annesi-MaesanoSorbonne Université and INSERM, Epidemiology of Allergic and Respiratory Diseases Dept (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Saint-Antoine Medical School, Paris, France.ORCID 0000-0002-6340-9300
Syed Hasan ArshadThe David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, UK.
Nour BaïzSorbonne Université and INSERM, Epidemiology of Allergic and Respiratory Diseases Dept (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Saint-Antoine Medical School, Paris, France.
Henrique BarrosEPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.ORCID 0000-0003-4699-6571
Andrea von BergResearch Institute, Dept of Pediatrics, Marien-Hospital Wesel, Wesel, Germany.
Hans BisgaardCOPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus BønnelykkeCOPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Christian J CarlssonCOPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Maribel CasasISGlobal, Barcelona, Spain.
Leda ChatziDept of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Cecile ChevrierUniversity Rennes, Inserm, Irset UMR_S 1085, Rennes, France.
Geertje DalmeijerJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Carol DezateuxInstitute of Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Karel DuchenCrown Princess Victoria Children's Hospital and Division of Pediatrics, Dept of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Merete EggesbøNorwegian Institute of Public Health, Oslo, Norway.
Cornelis van der EntDept of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Maria FantiniDept of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Claudia FlexederInstitute of Epidemiology I, Helmholtz Zentrum München, Munich, Germany.
Urs FreyUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Fransesco ForastiereDept of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-3612-5780
Davide GoriDept of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Raquel GranellMRC Intergrative Epidemiology Unit, Dept of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Lucy J GriffithsPopulation Data Science, Swansea University Medical School, Swansea, UK.
Hazel InskipNIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Joanna JerzynskaDept of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Anne M KarvonenDept of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland.ORCID 0000-0003-2257-2934
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Cecily KelleherSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Manolis KogevinasISGlobal, Barcelona, Spain.
Gudrun KoppenFlemish Institute for Technological Research (VITO), Environmental Risk and Health Unit, Mol, Belgium.
Claudia E KuehniInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.ORCID 0000-0001-8957-2002
Nathalie LambrechtsFlemish Institute for Technological Research (VITO), Environmental Risk and Health Unit, Mol, Belgium.
Susanne LauDept of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-5189-4265
Irina LehmannDept of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig - UFZ, Leipzig, Germany.
Johnny LudvigssonCrown Princess Victoria Children's Hospital and Division of Pediatrics, Dept of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Maria Christine MagnusMRC Intergrative Epidemiology Unit, Dept of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Erik MélenDept of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Sach's Children Hospital, Stockholm, Sweden.ORCID 0000-0002-8248-0663
John MeheganSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Monique MommersDept of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre+, Maastricht, The Netherlands.
Anne-Marie Nybo AndersenDept of Public Health, University of Copenhagen, Copenhagen, Denmark.
Wenche NystadDomain for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Eva S L PedersenInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.ORCID 0000-0003-0293-9954
Juha PekkanenDept of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland.ORCID 0000-0002-1083-8777
Ville PeltolaDept of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Katharine C PikeBristol Royal Hospital for Children, Bristol, UK.
Angela Pinot de MoiraDept of Public Health, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3593-8472
Costanza PizziDept of Medical Sciences, University of Turin, Turin, Italy.
Kinga PolanskaDept of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Maja PopovicDept of Medical Sciences, University of Turin, Turin, Italy.ORCID 0000-0003-4500-6572
Daniela PortaDept of Epidemiology, Lazio Regional Health Service, Rome, Italy.ORCID 0000-0002-3431-2729
Graham RobertsThe David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, UK.
Ana Cristina SantosEPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Erica S SchultzDept of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Sach's Children Hospital, Stockholm, Sweden.
Marie StandlInstitute of Epidemiology I, Helmholtz Zentrum München, Munich, Germany.
Jordi SunyerISGlobal, Barcelona, Spain.
Carel ThijsDept of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre+, Maastricht, The Netherlands.
Laura ToivonenDept of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Eleonora UphoffBorn in Bradford, Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
Jakob UsemannUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.ORCID 0000-0002-9987-2866
Marina VafeidiDept of Social Medicine, University of Crete, Heraklion, Greece.
John WrightBorn in Bradford, Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
Johan C de JongsteDept of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Liesbeth DuijtsDept of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands l.duijts@erasmusmc.nl.ORCID 0000-0001-6731-9452
Erasmus MC · NLUniversity of Copenhagen · DKInserm · FRNorwegian Institute of Public Health · NOUniversitat Pompeu Fabra · ESBradford Teaching Hospitals NHS Foundation Trust · GBFlemish Institute for Technological Research · BEHelmholtz Zentrum München · DEKarolinska Institutet · SELinköping University · SEMaastricht University Medical Centre · NLNofer Institute of Occupational Medicine · PLUniversity College Dublin · IEUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Basel · CHUniversity of Bern · CHUniversity of Bologna · ITUniversity of Helsinki · FIUniversity of Turin · ITUniversity of Turku · FI
Funding
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MEffects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicalsR01ES030364 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2024
$3.2MEnvironmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in YouthR01ES029944 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2023
$3.1MHepatotoxic effects of perfluoroalkyl substances: a new epidemiological approach for studying environmental fatty liver diseaseR01ES030691 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2022
$1.9MEpidemiology of asthma: risk and prognosis in a cohort from birth to adolescenceR01HL082925 · NHLBI · ST. MARY'S HOSPITAL NEWPORT · PI ARSHAD, SYED HASAN · 2007 to 2010
$1.7MThe adipose exposome effects on the plasma metabolome, body composition and metabolic outcomes after bariatric surgeryR21ES028903 · NIEHS · EMORY UNIVERSITY · PI CHATZI, VAIA LIDA, ZIEGLER, THOMAS R · 2018 to 2019
$455kDevelopmental origins of child liver injury: Effects of prenatal environmental exposuresR21ES029681 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2020
$453kHSRD VA TPR 15-230Medical Research Council 217065/Z/19/ZNHLBI NIH HHS R01 HL082925NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES029944NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01 ES030691NIEHS NIH HHS R21 ES028903NIEHS NIH HHS R21 ES029681Wellcome Trust
Abstract
backgroundEarly-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age.
methodsWe used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV
resultsChildren with early-life lower, not upper, respiratory tract infections had a lower school-age FEV
conclusionsOur findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
Indexed as
AsthmaRespiratory Tract InfectionsChild, PreschoolForced Expiratory VolumeHumansInfantLungProspective StudiesVital Capacity
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