ArticleCancer cell2022
Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.
Open access · bronzeAbstract readLetter
In one paragraph
Article in Cancer cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- cGAS-STING agonists in preclinical glioblastoma animal models: a systematic review of tumor microenvironment modulation and survival outcomes.Journal of neuro-oncology · 2026Pooled it
- PARP7 inhibition and a STING agonist potentiate radiation-induced immunogenicity in glioblastoma.Oncoimmunology · 2026Article
- The cGAS-STING/MITA pathway in innate antiviral immunity and beyond.Cell insight · 2026Review
- PARP inhibition enhances the antitumor activity of HER3-DXd in non-small cell lung cancer.Cell reports. Medicine · 2026Article
- Re-expression of MHC-I to treat CNS cancers.Oncotarget · 2026Review
- Resetting the immune setpoint of cold tumors through a ferroptosis-cGAS-STING amplification circuit.Journal of translational medicine · 2026Review
- Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026Review
- Dual-targeted manganese-doped carbon dots activate the cGAS-STING pathway and immunogenic cell death for potent glioblastoma immunotherapy.Materials today. Bio · 2026Article
- Rational design of a V-shaped DNA-targeted photosensitizer enables endogenous DNA damage-driven cGAS-STING activation and systemic antitumor immunity.Materials today. Bio · 2026Article
- Review
- cGAS-STING pathway in lung cancer and emerging therapeutic approaches.Drug discovery today · 2026Review
- SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres.Neuro-oncology · 2026Article
- Tumor-intrinsic chromatin programs enforce immune evasion in glioblastoma.The Journal of clinical investigation · 2026Article
- STING-induced blood-brain barrier opening combined with radiotherapy potentiates antitumor response in a high-grade glioma model.The Journal of clinical investigation · 2026Article
- STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.Nature communications · 2026Article
- Cell-type specific activation of the cGAS-STING pathway in tumor immunotherapy: mechanisms and therapeutic implications.Journal of translational medicine · 2026Review
- Precision targeting of STING: Challenges, innovations, and clinical outlook for cancer therapy.Innovation (Cambridge (Mass.)) · 2026Review
- The cGAS-STING pathway in cancer immunotherapy: prognostic value and therapeutic potential.Frontiers in immunology · 2026Review
- STING agonism in brain tumours: mechanisms, challenges, and therapeutic advances.Frontiers in oncology · 2026Review
- Targeting innate immunity to overcome immune evasion in HPV-associated cancers.Frontiers in cellular and infection microbiology · 2026Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Justin T LowDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Vidyalakshmi ChandramohanDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Michelle L BowieDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Michael C BrownDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Matthew S WaitkusDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Aaron BrileyDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Kevin StevensonMolecular Physiology Institute, Duke University Medical School, Durham, NC, USA.
Rebecca FullerDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Zachary J ReitmanDepartment of Radiation Oncology, Duke University Medical School, Durham, NC, USA.
Andrea M MuscatDepartment of Neurosciences, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Health, Melbourne, VIC, Australia.
Seethalakshmi HariharanDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Janell HostettlerDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Sarah DanehowerDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Ali BakerDepartment of Neurosciences, Monash University, Melbourne, VIC, Australia.
Mustafa KhasrawDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
Nicholas C WongMonash Bioinformatics Platform, Monash University, Clayton, VIC, Australia.
Simon GregoryMolecular Physiology Institute, Duke University Medical School, Durham, NC, USA.
Smita K NairDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA; Department of Surgery, Duke University Medical School, Durham, NC, USA; Department of Pathology, Duke University Medical School, Durham, NC, USA.
Amy HeimbergerDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Matthias GromeierDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA; Department of Molecular Genetics & Microbiology, Duke University Medical School, Durham, NC, USA.
Darell D BignerDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA.
David M AshleyDepartment of Neurosurgery, Duke University Medical School, Durham, NC, USA. Electronic address: david.ashley@duke.edu.
Duke University · USDuke Medical Center · USMonash University · AUAlfred Health · AUNorthwestern University · USUniversity of Louisville · US
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9MNCI NIH HHS P30 CA014051
Abstract
PubMed holds no abstract for this paper.
Indexed as
GliomaMethyltransferasesEpigenesis, GeneticHumansMethyltransferases
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.