Evidence map›Paper›PMID 35486714›Full record

ArticleACS infectious diseases2022

Glycomic Analysis Reveals a Conserved Response to Bacterial Sepsis Induced by Different Bacterial Pathogens.

Daniel W Heindel, Shuhui Chen, Peter V Aziz, Jonathan Y Chung, Jamey D Marth, Lara K Mahal

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  10. Elucidating the glycan-binding specificity and structure ofBeilstein journal of organic chemistry · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Daniel W HeindelBiomedical Research Institute, Department of Chemistry, New York University, New York, New York 10003, United States.
Shuhui ChenBiomedical Research Institute, Department of Chemistry, New York University, New York, New York 10003, United States.
Peter V AzizSBP Medical Discovery Institute, La Jolla, California 92037, United States.
Jonathan Y ChungBiomedical Research Institute, Department of Chemistry, New York University, New York, New York 10003, United States.
Jamey D MarthSBP Medical Discovery Institute, La Jolla, California 92037, United States.
Lara K MahalBiomedical Research Institute, Department of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0003-4791-8524
Biomedical Research Institute · USDiscovery Institute · USUniversity of Alberta · CA

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MARTH, JAMEY · 2016 to 2025
$26.2M
GLYCOSYLTRANSFERASE FUNCTION IN DEVELOPMENT AND DISEASER01DK048247 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMEY MARTH · 1994 to 2026
$9.4M
Acquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600k
NCI NIH HHS P30 CA016087NHLBI NIH HHS P01 HL131474NIDDK NIH HHS R01 DK048247NIH HHS S10 OD010582
6 · The paper itself

Abstract

Sepsis is an extreme inflammatory response to infection that occurs in the bloodstream and causes damage throughout the body. Glycosylation is known to play a role in immunity and inflammation, but the role of glycans in sepsis is not well-defined. Herein, we profiled the serum glycomes of experimental mouse sepsis models to identify changes induced by 4 different clinical bacterial pathogens (Gram-positive:

Indexed as

GlycomicsSepsisAnimalsBacteriaLectinsMicePolysaccharidesLectinsPolysaccharidescore 1/3 O-glycansfibronectininteralpha-trypsin inhibitor heavy chains (ITIHs)lectin microarraysepsisserum glycomics

Identifiers

PMID35486714
PMCPMC9112329
OpenAlexW4225256989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.