Evidence map›Paper›PMID 35486647›Full record

ArticleOcular immunology and inflammation2023

Relationship between Atopic Disease and Acute Ocular and Systemic Outcomes in Patients with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

James Kwan, Harris Ahmed, Momoko K Ponsetto, Tony Succar, James Chodosh, Hajirah N Saeed

Open access · greenAbstract read
In one paragraph

Article in Ocular immunology and inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

James KwanDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Harris AhmedDepartment of Ophthalmology, Loma Linda University Medical Center, Loma Linda, California, USA.
Momoko K PonsettoSchool of Medicine, Boston University, Boston, Massachusetts, USA.
Tony SuccarDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
James ChodoshDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Hajirah N SaeedDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Massachusetts Eye and Ear Infirmary · USBoston University · USHarvard University · USLoma Linda University Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Identification of genetic polymorphisms in Stevens Johnson syndrome and toxic epidermal necrolysisK23EY028230 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SAEED, HAJIRAH · 2018 to 2022
$1.3M
NCATS NIH HHS UL1 TR002541NEI NIH HHS K23 EY028230
6 · The paper itself

Abstract

objectiveTo describe the relationship between history of atopic disease on systemic and ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

methodsRetrospective chart review of patients with SJS/TEN patients. Those with and without prior atopic diagnosis were compared.

resultsIn total, 200 patients with SJS/TEN were identified. A total of 23 patients also had an atopic diagnosis. Four, 10, and 18 had atopic dermatitis, allergic rhinitis, and asthma respectively. Acute ocular severity was significantly worse in the atopic cohort. No significant differences in overall systemic severity of SJS or mortality were found between the atopic and non-atopic cohorts. Compared to our hospital system's general population, prevalence of an atopic diagnosis was significantly higher in those with SJS/TEN.

conclusionPatients with a history of an atopic diagnosis appear to have more significant acute ocular involvement during their SJS/TEN hospitalization. Atopic conditions appear to occur more frequently in the SJS/TEN population compared to the general population.

Indexed as

Dermatitis, AtopicEye DiseasesStevens-Johnson SyndromeEyeHumansRetrospective StudiesAllergic rhinitisasthmaatopic dermatitisatopic triadatopyStevens-Johnson syndrometoxic epidermal necrolysis

Identifiers

PMID35486647
PMCPMC10012391
OpenAlexW4225126437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.