ArticlePLoS neglected tropical diseases2022
Clinical characteristics and risk factors for severe scrub typhus in pediatric and elderly patients.
Article in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 11 citations in OpenAlex.
- Clinical characteristics and an admission-time predictive model for severe scrub typhus and secondary HLH in adults.BMC infectious diseases · 2026Article
- Analysis of the Epidemiological Characteristics and Risk Factors for Severe Progression of Scrub Typhus in the Dali Region of China.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Case Report: An imported severe case of paediatric scrub typhus with Karp B subgenotype in non-endemic Northern China, Beijing.Frontiers in pediatrics · 2026Article
- Development of a machine learning prognostic model for early prediction of scrub typhus progression at hospital admission based on clinical and laboratory features.Annals of medicine · 2025Article
- Development and validation of a simple-to-use nomogram for predicting severe scrub typhus in children.PLoS neglected tropical diseases · 2025Article
- Scrub Typhus in Kerala: Demographic, Clinical, and Laboratory Predictors of ICU Admission in a Tertiary Care Setting.Le infezioni in medicina · 2025Article
- The Effects of Patient Health Information Seeking in Online Health Communities on Patient Compliance in China: Social Perspective.Journal of medical Internet research · 2023Article
- Epidemiological analysis and risk prediction of scrub typhus from 2006 to 2021 in Sichuan, China.Frontiers in public health · 2023Review
- Clinical profile and biochemical abnormalities in Scrub Typhus: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScrub typhus (ST) is a life-threatening infectious disease if appropriate treatment is unavailable. Large discrepancy of clinical severity of ST patients was reported among age groups, and the underlying risk factors for severe disease are unclear.
methodsClinical and epidemiological data of ST patients were collected in 55 surveillance hospitals located in Guangzhou City, China, from 2012 to 2018. Severe prognosis and related factors were determined and compared between pediatric and elderly patients.
resultsA total of 2,074 ST patients including 209 pediatric patients and 1,865 elderly patients were included, with a comparable disease severity rate of 11.0% (95% CI 7.1%-16.1%) and 10.3% (95% CI 9.0%-11.8%). Different frequencies of clinical characteristics including lymphadenopathy, skin rash, enlarged tonsils, etc. were observed between pediatric and elderly patients. Presence of peripheral edema and decreased hemoglobin were the most important predictors of severe illness in pediatric patients with adjusted ORs by 38.99 (9.96-152.67, p<0.001) and 13.22 (1.54-113.50, p = 0.019), respectively, while presence of dyspnea and increased total bilirubin were the potential determinants of severe disease in elderly patients with adjusted ORs by 11.69 (7.33-18.64, p<0.001) and 3.17 (1.97-5.11, p<0.001), respectively. Compared with pediatric patients, elderly patients were more likely to receive doxycycline (64.8% v.s 9.9%, p<0.001), while less likely to receive azithromycin therapy (5.0% v.s 41.1%, p<0.001).
conclusionThe disease severity rate is comparable between pediatric and elderly ST patients, while different clinical features and laboratory indicators were associated with development of severe complications for pediatric and elderly patients, which is helpful for diagnosis and progress assessment of disease for ST patients.
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