Trial reportAmerican journal of physiology. Heart and circulatory physiology2022
Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test.
Trial report in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- A randomized controlled trial evaluating stress arousal reappraisal and worked example effects on psychophysiological responses during breaking bad news.Scientific reports · 2025Trial
- Body Posture-Related Differences in Pain Perception and Their Mediation by Cardiovascular Factors.Psychophysiology · 2026Article
- From protection to predisposition: A narrative review of sex-specific vascular responses to acute stressors across the lifespan.Physiological reports · 2026Review
- Sex-related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea.Experimental physiology · 2026Review
- Habitual sleep duration is associated with heightened muscle sympathetic nerve activation and blood pressure reactivity in response to the cold pressor test.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- The associations between cardiovascular and pain responses to a cold pressor test differ between males and females.European journal of applied physiology · 2025Article
- Sympathetic reactivity to emotional stress in women with major depressive disorder.Autonomic neuroscience : basic & clinical · 2025Article
- Elevated blood pressure, stroke volume, and vascular tone in young women who use oral contraception.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Sympathetic and blood pressure reactivity in young adults with major depressive disorder.Journal of affective disorders · 2024Article
- Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024Review
- Plethysmographic assessment of vasomotor response in patients with congestive heart failure before and after heart transplantation.Biomedical optics express · 2024Article
- Article
- Adjusting for muscle strength and body size attenuates sex differences in the exercise pressor reflex in young adults.American journal of physiology. Heart and circulatory physiology · 2023Article
- Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase.Experimental physiology · 2023Article
- The forearm vascular response to sympathetic activation is attenuated in female, but not male, participants following acute intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases.Journal of human hypertension · 2023Review
- Greater resting muscle sympathetic nerve activity reduces cold pressor autonomic reactivity in older women, but not older men.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Acute increases in sympathetic nervous system activity (SNA) often elicit peripheral vasoconstriction and increases in blood pressure (BP). Given sympathetic support of BP is modulated by ovarian sex hormones (e.g., estradiol), we sought to examine the effect of menstrual cycle and oral hormonal contraceptive pill (OC) phase on the hemodynamic response to acute increases in SNA. We hypothesized sympathoexcitation via cold pressor test (CPT) would elicit greater peripheral vasoconstriction and increases BP in females with natural menstrual cycles (NC) compared with females taking OC. We further hypothesized that SNA-mediated vasoconstriction would be attenuated during the high estradiol (HE) phase versus the low estradiol (LE) phase of the menstrual/pill cycle. Female NC (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.