Evidence map›Paper›PMID 35486424›Full record

ArticleeLife2022

Epistatic selection on a selfish

Beatriz Navarro-Dominguez, Ching-Ho Chang, Cara L Brand, Christina A Muirhead, Daven C Presgraves, Amanda M Larracuente

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026
    Article
  3. A selfish supergene causes meiotic drive through both sexes inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. New perspectives on the causes and consequences of male meiotic drive.Current opinion in genetics & development · 2023
    Review
  8. Meiotic drive of noncentromeric loci in mammalian meiosis II eggs.Current opinion in genetics & development · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Beatriz Navarro-DominguezDepartment of Biology, University of Rochester, Rochester, United States.ORCID 0000-0003-4077-8696
Ching-Ho ChangDepartment of Biology, University of Rochester, Rochester, United States.ORCID 0000-0001-9361-1190
Cara L BrandDepartment of Biology, University of Rochester, Rochester, United States.
Christina A MuirheadDepartment of Biology, University of Rochester, Rochester, United States.
Daven C PresgravesDepartment of Biology, University of Rochester, Rochester, United States.ORCID 0000-0003-4337-4072
Amanda M LarracuenteDepartment of Biology, University of Rochester, Rochester, United States.ORCID 0000-0001-5944-5686
University of Rochester · USRonin Institute · US

Funding

The evolutionary and functional genomics of satellite DNAR35GM119515 · NIGMS · UNIVERSITY OF ROCHESTER · PI Amanda Marie Larracuente · 2016 to 2026
$4.0M
The role of satellite rasiRNA in the Segregation Distorter system of DrosophilaF32GM105317 · NIGMS · UNIVERSITY OF ROCHESTER · PI LARRACUENTE, AMANDA MARIE · 2013 to 2014
$107k
NIGMS NIH HHS F32 GM105317NIGMS NIH HHS R35 GM119515
6 · The paper itself

Abstract

Meiotic drive supergenes are complexes of alleles at linked loci that together subvert Mendelian segregation resulting in preferential transmission. In males, the most common mechanism of drive involves the disruption of sperm bearing one of a pair of alternative alleles. While at least two loci are important for male drive-the driver and the target-linked modifiers can enhance drive, creating selection pressure to suppress recombination. In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system,

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsChromosome InversionDrosophilaGenetic LoadMaleMeiosisRecombination, GeneticSelection, GeneticDrosophila Proteinschromosomal inversionsD. melanogasterepistatic selectionevolutionary biologygeneticsgenomicsmeiotic drivepopulation genomicssupergene

Identifiers

PMID35486424
PMCPMC9122502
OpenAlexW4226354943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.