ArticleNeuroinformatics2022
Cortical Representation of Touch in Silico.
Article in Neuroinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Information transfer and recovery for the sense of touch.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cell-type-specific firing patterns in a V1 cortical column model depend on feedforward and feedback-driven states.PLoS computational biology · 2025Article
- Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types.Frontiers in computational neuroscience · 2025Article
- NeuroCarta: An automated and quantitative approach to mapping cellular networks in the mouse brain.Network neuroscience (Cambridge, Mass.) · 2025Article
- Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia.Frontiers in neuroanatomy · 2023Review
- Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE.Frontiers in neuroinformatics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With its six layers and ~ 12,000 neurons, a cortical column is a complex network whose function is plausibly greater than the sum of its constituents'. Functional characterization of its network components will require going beyond the brute-force modulation of the neural activity of a small group of neurons. Here we introduce an open-source, biologically inspired, computationally efficient network model of the somatosensory cortex's granular and supragranular layers after reconstructing the barrel cortex in soma resolution. Comparisons of the network activity to empirical observations showed that the in silico network replicates the known properties of touch representations and whisker deprivation-induced changes in synaptic strength induced in vivo. Simulations show that the history of the membrane potential acts as a spatial filter that determines the presynaptic population of neurons contributing to a post-synaptic action potential; this spatial filtering might be critical for synaptic integration of top-down and bottom-up information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.