Evidence map›Paper›PMID 35486121›Full record

ArticlePsychopharmacology2022

The CannTeen study: verbal episodic memory, spatial working memory, and response inhibition in adolescent and adult cannabis users and age-matched controls.

W Lawn, N Fernandez-Vinson, C Mokrysz, G Hogg, R Lees, K Trinci, K Petrilli, A Borissova, S Ofori, S Waters and 4 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

W LawnClinical Psychopharmacology Unit, University College London, London, UK. will.lawn@kcl.ac.uk.
N Fernandez-VinsonClinical Psychopharmacology Unit, University College London, London, UK.
C MokryszClinical Psychopharmacology Unit, University College London, London, UK.
G HoggClinical Psychopharmacology Unit, University College London, London, UK.
R LeesAddiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
K TrinciClinical Psychopharmacology Unit, University College London, London, UK.
K PetrilliAddiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
A BorissovaDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
S OforiClinical Psychopharmacology Unit, University College London, London, UK.
S WatersDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
P MichórSchool of Life Sciences, University of Warwick, Coventry, UK.
M B WallClinical Psychopharmacology Unit, University College London, London, UK.
T P FreemanClinical Psychopharmacology Unit, University College London, London, UK.
H V CurranClinical Psychopharmacology Unit, University College London, London, UK.
University College London · GBUniversity of Bath · GBUniversity of Manchester · GBUniversity of Warwick · GBWarneford Hospital · GB

Funding

Medical Research Council MR/P012728/1
6 · The paper itself

Abstract

backgroundPreclinical and human studies suggest that adolescent cannabis use may be associated with worse cognitive outcomes than adult cannabis use. We investigated the associations between chronic cannabis use and cognitive function in adolescent and adult cannabis users and controls. We hypothesised user-status would be negatively associated with cognitive function and this relationship would be stronger in adolescents than adults.

methodsAs part of the 'CannTeen' project, this cross-sectional study assessed cognitive performance in adolescent cannabis users (n = 76; 16-17-year-olds), adolescent controls (n = 63), adult cannabis users (n = 71; 26-29-year-olds) and adult controls (n = 64). Users used cannabis 1-7 days/week. Adolescent and adult cannabis users were matched on cannabis use frequency (4 days/week) and time since last use (2.5 days). Verbal episodic memory (VEM) was assessed using the prose recall task, spatial working memory (SWM) was assessed using the spatial n-back task, and response inhibition was assessed with the stop-signal task. Primary outcome variables were: delayed recall, 3-back discriminability, and stop signal reaction time, respectively.

resultsUsers had worse VEM than controls (F(1,268) = 7.423, p = 0.007). There were no significant differences between user-groups on SWM or response inhibition. Null differences were supported by Bayesian analyses. No significant interactions between age-group and user-group were found for VEM, SWM, or response inhibition.

conclusionsConsistent with previous research, there was an association between chronic cannabis use and poorer VEM, but chronic cannabis use was not associated with SWM or response inhibition. We did not find evidence for heightened adolescent vulnerability to cannabis-related cognitive impairment.

Indexed as

CannabisMemory, EpisodicAdolescentAdultBayes TheoremCognitionCross-Sectional StudiesHumansMemory, Short-TermNeuropsychological TestsAdolescenceCannabisCognitionEpisodic memoryMarijuanaMemoryResponse inhibitionVerbal memoryWorking memory

Identifiers

PMID35486121
PMCPMC9110435
OpenAlexW4225531950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.