ArticleeLife2022
Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- KFrontiers in neurology · 2024Pooled it
- Development of a standardized intracranial vessel model from 3D time-of-flight magnetic resonance angiography data of the SHIP cohort.Neuroradiology · 2026Article
- Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains.bioRxiv : the preprint server for biology · 2026Article
- VesSynth: Tubes Are All You Need for Robust Cross-Scale Cross-Modal 3D Vessel Segmentation.bioRxiv : the preprint server for biology · 2026Article
- The Extremely Brilliant Brain: An Isotropic Microscale Human Brain Dataset.bioRxiv : the preprint server for biology · 2026Article
- TMagnetic resonance in medicine · 2026Article
- Whole-brain meso-vein imaging in living humans using fast 7-T MRI.Science advances · 2026Article
- Voxel-accurate MRI-microscopy Correlation Enables AI-powered Prediction of Brain Disease States.Theranostics · 2026Article
- Using PINS pulses to saturate inflow effects on fMRI data at 3 and 7 T.Magnetic resonance in medicine · 2025Article
- Quantitative analysis of cerebral vasculature and its clinical effect on cognitive change in Alzheimer's dementia and mild cognitive impairment.Journal of the neurological sciences · 2025Article
- Assessing Arterial Patterns in the Motor Cortex With 7 Tesla Magnetic Resonance Imaging and Vessel Distance Mapping.Human brain mapping · 2025Article
- Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan.PLoS biology · 2025Article
- Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI.eLife · 2025Article
- High-resolution 0.16-mm time-of-flight angiography at 7 T with volumetric navigators for prospective motion correction.Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition · 2025Article
- Characterizing positive and negative quantitative susceptibility values in the cortex following mild traumatic brain injury: a depth- and curvature-based study.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Macrovascular contributions to resting-state fMRI signals: A comparison between EPI and bSSFP at 9.4 Tesla.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Non-contrast enhanced visualization of the equine foot vasculature in a cadaver model using time-of-flight sequence.Frontiers in veterinary science · 2025Article
- Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney.Scientific reports · 2024Article
- Self-supervised learning for accurately modelling hierarchical evolutionary patterns of cerebrovasculature.Nature communications · 2024Article
- Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging - A Symposium Review.Neuroinformatics · 2024Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
Abstract
The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic arteries (diameter 50-300 µm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight magnetic resonance angiography (TOF-MRA)-which is well suited to high 3D imaging resolutions-has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140 µm isotropic resolution using a 7 Tesla (T) magnetic resonance imaging (MRI) scanner and prospective motion correction, and show that pial arteries one voxel width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.