Evidence map›Paper›PMID 35485989›Full record

ArticleAllergy2022

Real-life evaluation of molecular multiplex IgE test methods in the diagnosis of pollen associated food allergy.

Luisa Diem, Bellinda Neuherz, Johanna Rohrhofer, Larissa Koidl, Riccardo Asero, Knut Brockow, Araceli Diaz Perales, Margaretha Faber, Julia Gebhardt, María José Torres and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  13. Selected Technical Aspects of Molecular Allergy Diagnostics.Current issues in molecular biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

Luisa DiemInstitute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Bellinda NeuherzInstitute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Johanna RohrhoferInstitute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Larissa KoidlInstitute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-9974-7929
Riccardo AseroAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.ORCID 0000-0002-8277-1700
Knut BrockowDepartment of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany.ORCID 0000-0002-2775-3681
Araceli Diaz PeralesCentro de Biotecnología Y Genómica de Plantas (CBGP, UPM-INIA), Universidad Politécnica de Madrid (UPM) -Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain.ORCID 0000-0002-1093-3627
Margaretha FaberDepartment of Dermatology AZ KLINA, Brasschaat, Belgium.
Julia GebhardtDepartment of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany.
María José TorresAllergy Unit, Hospital Regional Universitario de Málaga, Universidad de Málaga-IBIMA-BIONAND, Málaga, Spain.ORCID 0000-0001-5228-471X
Erika Jensen-JarolimInstitute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4019-5765
Sonja ZehetmayerCenter for Medical Statistics, Informatics and Intelligent Systems (Institute of Medical Statistics), Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6863-7997
Eva UntersmayrInstitute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1963-499X
Medical University of Vienna · ATTechnical University of Munich · DEAZ Klina · BEHospital Regional Universitario de Málaga · ESInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESOspedale San Carlo · ITStatistics Austria · ATUniversity of Veterinary Medicine Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnosis of food allergies is challenging, as combining information from specific IgE (sIgE)-sensitization pattern and skin prick tests (SPTs) with clinical history is necessary for a personalized management of allergic patients. The aim of this study was to compare two molecular tests, the ImmunoCAP ISAC (ISAC) and the Allergy Explorer, version 2 (ALEX

methodsDiagnosis of food allergy was performed in 53 patients. Allergen-sIgE concentrations were measured with ISAC and ALEX

resultsUsing ISAC as reference test for sIgE measurements, the average sensitivity of ALEX

conclusionMultiplex testing is beneficial to understand patient-specific individual sensitization profiles and to providing personalized management recommendations. In the future, custom-designed test kits might enable reducing costs of multiplex testing for specific patient groups without compromising the diagnostic value.

Indexed as

Food HypersensitivityProfilinsAllergensHumansImmunoglobulin EPollenSkin TestsAllergensImmunoglobulin EProfilinsfood allergymolecular diagnosismultiplex testingpollen food syndrome

Identifiers

PMID35485989
PMCPMC9790655
OpenAlexW4225158094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.