ArticleVascular medicine (London, England)2022
Frailty and outcomes following revascularization of lower-extremity peripheral artery disease: Insights from the Vascular Quality Initiative (VQI).
Article in Vascular medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- The Modified 5-Item Frailty Index Is a Predictor of Perioperative Complications in Digital Replantation.Hand (New York, N.Y.) · 2026Article
- Long-term patency of aortoiliac stenting with or without simultaneous infrainguinal revascularization: a propensity score-matched 10-year retrospective cohort study.Annals of surgical treatment and research · 2026Article
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- Reporting and analysis of sex in vascular surgery research.Journal of vascular surgery · 2024Review
- Decision making in the frail vascular surgery patient: A scoping review.Seminars in vascular surgery · 2024Article
- Prognostic Value of Hospital Frailty Risk Score and Clinical Outcomes in Patients Undergoing Revascularization for Critical Limb-Threatening Ischemia.Journal of the American Heart Association · 2023Article
- Seeing the entire elephant: The challenges of frailty assessment for peripheral artery disease.Vascular medicine (London, England) · 2022Article
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple frailty screening tools are implemented; however, it is unclear whether they perform in a comparable way for both frailty detection and prediction of perioperative outcomes in patients undergoing lower-extremity revascularization.
methodsPatients undergoing lower-extremity revascularization were identified from the Vascular Quality Initiative (VQI) national database. Two cohorts were established based on the revascularization type (percutaneous vascular interventions (PVI) or lower-extremity bypass). Frailty was assessed by the 5-item modified frailty index (mFI-5) and the VQI-derived risk analysis index (RAI).
resultsOut of 134,081 patients undergoing PVI, frailty was identified in 67% by mFI-5 and 28% by RAI. Similarly, out of 41,316 patients in the bypass cohort, frailty was identified in 69% by mFI-5 and 16% by RAI. There was little agreement between the two frailty tools for both vascular cohorts (PVI: kappa: 0.17; bypass: kappa: 0.13). In an adjusted analysis, frailty as assessed by mFI-5 and RAI was associated with higher odds of mortality in both cohorts (
conclusionThere was significant variation in frailty detection by mFI-5 and RAI. Although frailty was associated with mortality, the predictive value of these tools in predicting outcomes in PAD was limited. Future research should focus on designing new frailty screening tools specific to the PAD population.
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