Evidence map›Paper›PMID 35485347›Full record

ArticleAntiviral therapy

Virus reactivation in a non-cirrhotic HBV patient requiring liver transplantation after cessation of nucleoside analogue therapy.

Han Zhang, Fang Chen, Erick Giang, Fei Bao, Georg M Lauer, Christopher Marsh, Mansun Law, Paul J Pockros

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Han ZhangDivision of Gastroenterology/Hepatology, 2697Scripps Clinic, La Jolla, CA, USA.
Fang ChenDepartment of Immunology and Microbiology, 478079The Scripps Research Institute, La Jolla, CA, USA.
Erick GiangDepartment of Immunology and Microbiology, 478079The Scripps Research Institute, La Jolla, CA, USA.
Fei BaoDepartment of Pathology, Scripps Clinic, La Jolla, CA, USA.
Georg M LauerGastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Christopher MarshScripps Center for Organ Transplantation, Scripps Clinic, La Jolla, CA, USA.
Mansun LawDepartment of Immunology and Microbiology, 478079The Scripps Research Institute, La Jolla, CA, USA.
Paul J PockrosDivision of Gastroenterology/Hepatology, 2697Scripps Clinic, La Jolla, CA, USA.
Scripps Clinic · USScripps Research Institute · USMassachusetts General Hospital · US

Funding

Understanding human neutralizing antibodies to hepatitis C virusR01AI079031 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI LAW, MANSUN · 2008 to 2017
$4.6M
Novel HCV vaccine antigens targeting conserved neutralizing epitopesU19AI123861 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ZHU, JIANG · 2016 to 2020
$4.6M
NIAID NIH HHS R01 AI079031NIAID NIH HHS U19 AI123861
6 · The paper itself

Abstract

Nucleos(t)ide analogues (NAs) are a mainstay of therapy for chronic hepatitis B (CHB) infections and have a profound effect on hepatitis B virus (HBV) suppression. We report a rare case of HBV reactivation in a CHB patient without cirrhosis following cessation of NA therapy that resulted in acute liver failure requiring liver transplantation. Investigation of the viral genetics and host immune responses suggest that viral mutations known to promote virus replication are associated with reactivation, whereas adaptive immunity to HBV remained defective in this patient. Viral sequencing may be useful for identifying mutations that are unfavorable for therapy withdrawal.

Indexed as

Hepatitis B, ChronicLiver TransplantationAntiviral AgentsHepatitis B virusHumansNucleosidesAntiviral AgentsNucleosides

Identifiers

PMID35485347
PMCPMC9272995
OpenAlexW3202931534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.