Evidence map›Paper›PMID 35485233›Full record

ArticleBioengineered2022

P75 neurotrophin receptor positively regulates the odontogenic/osteogenic differentiation of ectomesenchymal stem cells via nuclear factor kappa-B signaling pathway.

Peifen Shan, Xiaole Wang, Yanyan Zhang, Zhisheng Teng, Yunxiao Zhang, Qiu Jin, Jiefan Liu, Jianfeng Ma, Xin Nie

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. p75Bone reports · 2025
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Peifen ShanDepartment of Prosthodontics, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Xiaole WangDepartment of Nursing, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yanyan ZhangDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Zhisheng TengDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yunxiao ZhangDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Qiu JinDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Jiefan LiuDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Jianfeng MaDepartment of Prosthodontics, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Xin NieDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-4645-226X
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p75NTR, a neural crest stem cell marker, is continuously expressed in mesenchymal cells during tooth development. Importantly, high expression of p75NTR in the late bell stage implicates its involvement in odontogenesis and mineralization. However, the regulatory mechanisms underlying p75NTR involvement in odonto/osteogenic differentiation remain unclear. Here, we investigate the effect and potential mechanisms underlying p75NTR involvement in odonto/osteogenic differentiation. We dissected EMSCs from the first branchial arches of mice embryo and compared the proliferation and migration of p75NTR

Indexed as

Mesenchymal Stem CellsOsteogenesisAlkaline PhosphataseAnimalsCells, CulturedMiceNF-kappa BOdontogenesisReceptor, Nerve Growth FactorReceptors, Nerve Growth FactorSignal TransductionAlkaline PhosphataseNF-kappa BNgfr protein, mouseReceptor, Nerve Growth FactorReceptors, Nerve Growth Factorp75NTR MSCs NF-κB cell differentiation tooth development

Identifiers

PMID35485233
PMCPMC9208484
OpenAlexW4225114877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.