ArticleActa paediatrica (Oslo, Norway : 1992)2022
Associations of preterm birth, small-for-gestational age, preeclampsia and placental abruption with attention-deficit/hyperactivity disorder in the offspring: Nationwide cohort and sibling-controlled studies.
Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis.PLoS medicine · 2025Pooled it
- The association between maternal diabetes and the risk of attention deficit hyperactivity disorder in offspring: an updated systematic review and meta-analysis.European child & adolescent psychiatry · 2025Pooled it
- The impact and mechanisms of preeclampsia on offspring neurodevelopment.Cell & bioscience · 2026Review
- Risk factors for developmental delays in small for gestational age children at age of 24-36 months.European child & adolescent psychiatry · 2026Article
- Health and Development of Children Born Moderate and Late Preterm and Early Term at Age 10 in French Birth Cohorts ELFE and EPIPAGE 2.Paediatric and perinatal epidemiology · 2026Article
- Neurodevelopmental risks of late-preterm and early-term births: a population-based study from Finland.BMJ public health · 2026Article
- Early and multicomponent intervention after adverse pregnancy outcomes: an opportunity to win hearts and minds.European heart journal · 2025Article
- Postpartum Depression Increases the Risk of Childhood Attention Deficit Hyperactivity Disorder Diagnosis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Development of a new data management system for the study of the gut microbiome of children who are small for their gestational age.Computational and structural biotechnology journal · 2025Article
- Neurological development in children born moderately or late preterm: national cohort study.BMJ (Clinical research ed.) · 2024Article
- [Recent research on the long-term neurodevelopmental outcomes of very preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Preterm or early term birth and risk of attention-deficit/hyperactivity disorder: a national cohort and co-sibling study.Annals of epidemiology · 2023Article
- A Narrative Review of the Association between Prematurity and Attention-Deficit/Hyperactivity Disorder and Accompanying Inequities across the Life-Course.Children (Basel, Switzerland) · 2023Review
- Associations of preterm birth, small-for-gestational age, preeclampsia and placental abruption with attention-deficit/hyperactivity disorder in the offspring: Nationwide cohort and sibling-controlled studies.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
aimThe aim of this study was to investigate preterm birth, small-for-gestational age (SGA), preeclampsia and placental abruption in relation to attention-deficit/hyperactivity disorder (ADHD) in offspring.
methodsWe conducted a population-based cohort study among non-malformed live-born singleton children in Sweden born during 2002-2014. Using national registries with recorded information, we followed 1,212,201 children for an ADHD diagnosis from 3 to 15 years. We compared ADHD rates between exposure categories using adjusted hazard ratios (HR) with 95% confidence intervals (CI) from Cox proportional hazards models. We also conducted sibling-controlled analyses among 751,464 full siblings.
resultsThere were 27,665 ADHD diagnoses in the cohort. Compared with term birth (≥37 weeks), adjusted HR (95% CI) for ADHD increased with decreasing gestational age: 1.18 (1.11, 1.25), 1.61 (1.37, 1.89) and 2.79 (2.23, 3.49) for 32-36 weeks, 28-31 weeks and 22-27 weeks. Both spontaneous and medically indicated preterm birth were associated with ADHD. SGA was related to 1.62 (1.49, 1.77) times higher ADHD incidence. Preeclampsia, but not placental abruption, was associated with ADHD. Sibling-controlled analyses showed similar results. Preterm birth did not fully explain the associations of SGA or preeclampsia with ADHD.
conclusionPreterm birth, SGA and preeclampsia are related to ADHD incidence in offspring.
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Registered trials
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