ArticleInternational journal for numerical methods in biomedical engineering2022
A coupled computational framework for bone fracture healing and long-term remodelling: Investigating the role of internal fixation on bone fractures.
Article in International journal for numerical methods in biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Evaluating the age of rib fractures throughInternational journal of legal medicine · 2026Article
- Computational models for predicting bone fracture healing: a review of modeling approaches, predictions, and emerging strategies.Biomechanics and modeling in mechanobiology · 2026Review
- Genomechanical modeling of delayed fracture healing integrating transcriptomics and tissue mechanics.Biomaterials advances · 2026Article
- In Silico possibilities to understand peri-implant bone healing- state of the Art.International journal of implant dentistry · 2025Review
- [A study on the predictive model of porous hyperelastic properties of human alveolar bone based on computed tomography imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Mechanobiological cues to bone cells during early metastasis drive later osteolysis: A computational mechanoregulation framework prediction.Mechanobiology in medicine · 2025Article
- A computational optimisation study of hip implant using density mapping functionally graded biomimetic TPMS-based lattice structures.NPJ metamaterials · 2025Article
- A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents.Scientific reports · 2024Article
- A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.Frontiers in bioengineering and biotechnology · 2024Article
- Article
- A coupled computational framework for bone fracture healing and long-term remodelling: Investigating the role of internal fixation on bone fractures.International journal for numerical methods in biomedical engineering · 2022Article
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3 authors.
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Abstract
In this study, a coupled computational modelling framework for bone fracture repair is presented that enables predictions of both healing and remodelling phases of the fracture region and is used to investigate the role of an internal fixation plate on the long-term healing performance of a fracture tibia under a range of different conditions. It was found that introduction of a titanium plate allowed the tibia to undergo successful healing at higher loading conditions and fracture gaps, compared with the non-plated versions. While these plated cases showed faster rates of repair in the healing phase, their performance was substantially different once they entered the remodelling phase, with substantial regions of stress shielding predicted. This framework is one of the few implementations of both fracture healing and remodelling phases of bone repair and includes several innovative approaches to smoothing, time-averaging and time incrementation in its implementation, thereby avoiding any unwanted abrupt changes between tissue phenotypes. This provides a better representation of tissue development in the fracture site when compared with fracture healing models alone and provides a suitable platform to investigate the long-term performance of orthopaedic fixation devices. This would enable the more effective design of permanent fixation devices and optimisation of the spatial and temporal performance of bioabsorbable implants.
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