Evidence map›Paper›PMID 35484936›Full record

ArticleEuropean journal of clinical investigation2022

Mental health conditions and risk of first-ever ischaemic stroke and death in patients with incident atrial fibrillation: A nationwide cohort study.

Konsta Teppo, Jussi Jaakkola, Fausto Biancari, Olli Halminen, Jukka Putaala, Pirjo Mustonen, Jari Haukka, Miika Linna, Janne Kinnunen, Paula Tiili and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Konsta TeppoUniversity of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-4460-0994
Jussi JaakkolaUniversity of Turku, Turku, Finland.
Fausto BiancariHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Olli HalminenDepartment of Industrial Engineering and Management, Aalto University, Espoo, Finland.
Jukka PutaalaNeurology, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
Pirjo MustonenHeart Center, Turku University Hospital, Turku, Finland.
Jari HaukkaUniversity of Helsinki, Helsinki, Finland.
Miika LinnaAalto University, Espoo, Finland.
Janne KinnunenNeurology, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
Paula TiiliUniversity of Helsinki, Helsinki, Finland.
Elis KoukiUniversity of Helsinki, Helsinki, Finland.
Tero PenttiläHeart Hospital, Tampere University Hospital, Tampere, Finland.
Juha HartikainenUniversity of Eastern Finland, Kuopio, Finland.
Aapo L AroHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
K E Juhani AiraksinenUniversity of Turku, Turku, Finland.
Mika LehtoHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
University of Helsinki · FIUniversity of Turku · FIUniversity of Eastern Finland · FIAalto University · FITampere University Hospital · FITurku University Hospital · FI

Funding

Aarne Koskelon SäätiöHelsingin ja Uudenmaan SairaanhoitopiiriSydäntutkimussäätiö
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) patients with mental health conditions (MHCs) have higher incidence of ischaemic stroke (IS) than patients without MHC, but whether this results from direct impact of MHCs or relates to higher prevalence of comorbidities and differences in the use of oral anticoagulant (OAC) therapy is unclear. We assessed the hypothesis that MHCs independently increase the risk of IS in patients with incident AF.

methodsThe nationwide FinACAF cohort covered all 203,154 patients diagnosed with incident AF without previous IS or transient ischaemic attack in Finland during 2007-2018. MHCs of interest were depression, bipolar disorder, anxiety disorder, schizophrenia and any MHC. The outcomes were first-ever IS and all-cause death.

resultsThe patients' (mean age 73.0 ± 13.5 years, 49.0% female) mean follow-up time was 4.3 (SD 3.3) years and 16,272 (8.0%) experienced first-ever IS and 63,420 (31.2%) died during follow-up. After propensity score matching and adjusting for OAC use, no MHC group was associated with increased IS risk (adjusted SHRs (95% CI): depression 0.961 (0.857-1.077), bipolar disorder 1.398 (0.947-2.006), anxiety disorder 0.878 (0.718-1.034), schizophrenia 0.803 (0.594-1.085) and any MHC 1.033 (0.985-1.085)). Lower rate of OAC use partly explained the observed higher crude IS incidence in patients with any MHC. Depression, schizophrenia and any MHC were associated with higher all-cause mortality (adjusted HRs [95% CI]: 1.208 [1.136-1.283], 1.543 [1.352-1.761] and 1.149 [1.116-1.175], respectively).

conclusionsIn this nationwide retrospective cohort study, MHCs were not associated with the incidence of first-ever IS in patients with AF.

Indexed as

Atrial FibrillationBrain IschemiaIschemic StrokeStrokeAdministration, OralAgedAged, 80 and overAnticoagulantsCohort StudiesFemaleHumansMaleMental HealthMiddle AgedRetrospective StudiesRisk FactorsAnticoagulantsatrial fibrillationischaemic strokemental health conditionsmortalitypsychiatric disorders

Identifiers

PMID35484936
PMCPMC9539593
OpenAlexW4225146249

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.