Evidence map›Paper›PMID 35484464›Full record

ReviewJournal of cardiovascular translational research2022

The Mechanisms Underlying the Beneficial Effects of Stem Cell-Derived Exosomes in Repairing Ischemic Tissue Injury.

Yu Zhang, Lijuan Jiao, Lin Lu, Chengjie Wu, Junchu Tu, Yujie Li, Yanli Wang, Fengzhi Ding, Wei Luo, Wenjie Chen and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu Zhang *Institute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Lijuan Jiao *Institute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Lin LuInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Chengjie WuInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Junchu TuInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Yujie LiInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Yanli WangInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Fengzhi DingInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Wei LuoInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Wenjie ChenInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Zhenya ShenInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Yao-Hua SongCyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China. yaohua_song1@yahoo.com.
Yangxin LiInstitute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China. yangxin_li@yahoo.com.ORCID 0000-0002-2364-3207

Funding

Introduction Project of Clinical Medicine Expert Team for Suzhou SZYJTD201704Jiangsu Province Peak of Talent in Six Industries BU24600117National Natural Science Foundation of China 81870194National Natural Science Foundation of China 81873528National Natural Science Foundation of China 91839101National Natural Science Foundation of China 91849122
6 · The paper itself

Abstract

Ischemic diseases are life-threatening, and the incidence increases as people's lifestyles change. Medications and surgical intervention offer limited benefit, and stem cell therapy has emerged as a potential approach for treating ischemic diseases. The exosomes secreted by stem cells have attracted more attention because they do not trigger the immune response and can be used as drug carriers. The non-coding RNA (ncRNA) carried by exosomes plays a key role in mediating exosome's beneficial effect, which can be further enhanced when combined with nanomaterials to improve its retention time. Here, we review the downstream target molecules and signal pathways of ncRNA and summarize recent advances of some nanomaterials used to encapsulate exosomes and promote ischemic tissue repair. We highlight the imprinting of exosomes from parent cells and discuss how the inflammasome pathway may be targeted for the development of novel therapy for ischemic diseases.

Indexed as

ExosomesHumansIschemiaSignal TransductionStem Cell TransplantationExosomeInflammasomeIschemic diseasesNanomaterialncRNA

Identifiers

PMID35484464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.