Evidence map›Paper›PMID 35484406›Full record

ArticleNature neuroscience2022

Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes.

Moritz Armbruster, Saptarnab Naskar, Jacqueline P Garcia, Mary Sommer, Elliot Kim, Yoav Adam, Philip G Haydon, Edward S Boyden, Adam E Cohen, Chris G Dulla

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Article
  3. Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Membrane voltage multistability in coupled glial cells.bioRxiv : the preprint server for biology · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Astrocytes as Active Participants in Memory.Journal of neurochemistry · 2025
    Review
  17. CRISPR-edited iPSCs reveal BSN gene mutations induce neuronal hyperexcitability via astrocyte lipid accumulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  18. Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Moritz ArmbrusterDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA. Moritz.Armbruster@tufts.edu.ORCID 0000-0003-2341-513X
Saptarnab NaskarDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-8435-4484
Jacqueline P GarciaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Mary SommerDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Elliot KimDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Yoav AdamDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Philip G HaydonDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0001-5698-6698
Edward S BoydenDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-0419-3351
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8699-2404
Chris G DullaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA. Chris.Dulla@tufts.edu.ORCID 0000-0002-6560-6535
Tufts University · USHarvard University · USHoward Hughes Medical Institute · US

Funding

Voltage Imaging of Astrocyte-Neuron InteractionsR01NS113499 · NINDS · TUFTS UNIVERSITY BOSTON · PI DULLA, CHRIS G · 2019 to 2023
$3.7M
Voltage-dependent modulation of astrocyte glutamate transport induced by neuronal activityR21NS104478 · NINDS · TUFTS UNIVERSITY BOSTON · PI DULLA, CHRIS G · 2017 to 2018
$454k
Howard Hughes Medical InstituteNINDS NIH HHS R01 NS113499NINDS NIH HHS R21 NS104478
6 · The paper itself

Abstract

Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium (K

Indexed as

AstrocytesNeuronsAnimalsGlutamic AcidMiceNeurogliaSynapsesGlutamic Acid

Identifiers

PMID35484406
PMCPMC9988390
OpenAlexW4225147667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.