Evidence map›Paper›PMID 35484360›Full record

ArticleJournal of cancer research and clinical oncology2023

Serum lactate dehydrogenase as a novel prognostic factor for patients with primary undifferentiated pleomorphic sarcomas.

Qiaowei Lin, Zhengwang Sun, Lin Yu, Qifeng Wang, Ping Zhu, Yihan Jiang, Yangbai Sun, Wangjun Yan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qiaowei Lin *Department of Musculoskeletal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, 200030, China.
Zhengwang Sun *Department of Musculoskeletal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, 200030, China.
Lin Yu *Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Qifeng WangDepartment of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Ping ZhuDepartment of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Yihan JiangDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yangbai SunDepartment of Musculoskeletal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, 200030, China. drsunyb@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2853-2813
Wangjun YanDepartment of Musculoskeletal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, 200030, China. yanwj@fudan.edu.cn.
Fudan University Shanghai Cancer Center · CNShanghai First People's Hospital · CN

Funding

National Natural Science Foundation of China 81672851National Natural Science Foundation of China 81701937National Natural Science Foundation of China 81872179
6 · The paper itself

Abstract

purposeAmong soft tissue sarcomas, undifferentiated pleomorphic sarcoma (UPS) has relatively higher potential of recurrence and metastasis. As serum lactate dehydrogenase (LDH) is associated with tumor progression and unfavorable outcomes in multiple malignancies, we designed this study to explore the relationship between preoperative serum LDH and prognosis in UPS patients.

methodsWe extracted the data of UPS patients who underwent primary surgery in Shanghai Cancer Center, Fudan University. Receiver-operating characteristic (ROC) curve was used to figure out the best cutoff value of LDH to classify them into high- or low-expression groups. Univariate and multivariate analyses were performed using Cox proportional hazards regression to identify independent prognostic factors. Kaplan-Meier analysis was used to compare differences in overall survival (OS) and time to recurrence (TTR) between patients with high- or low-serum LDH.

resultsMultivariate analyses demonstrated that preoperative serum LDH was an independent factor for OS. Kaplan-Meier curves showed that patients with relatively high-serum LDH (P = 0.0004) had poorer OS compared with those with low-serum LDH. There was a trend that patients with relatively high-serum LDH had poorer TTR than those without (P = 0.1249). In addition, there were obvious trends that patients with decreased serum LDH after surgery showed better OS (P = 0.0954) and TTR (P = 0.1720) than those with elevated serum LDH. Moreover, high preoperative serum LDH was associated with female patients (P = 0.0004), positive margin (P < 0.0001), worse survival (P = 0.0061), higher mitotic index (P = 0.0222) and necrosis (P = 0.0225).

conclusionsPreoperative serum LDH is an independent factor for OS in UPS patients, and it correlates with future surgical margin.

Indexed as

SarcomaChinaFemaleHumansKaplan-Meier EstimateLactate DehydrogenasesPrognosisLactate DehydrogenasesLactate dehydrogenaseLong-term follow-upPrognostic factorSurvivalUndifferentiated pleomorphic sarcomas

Identifiers

PMID35484360
PMCPMC11797317
OpenAlexW4225133054

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.