Evidence map›Paper›PMID 35484242›Full record

ArticleMolecular psychiatry2022

Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.

Mahendra Wagle, Mahdi Zarei, Matthew Lovett-Barron, Kristina Tyler Poston, Jin Xu, Vince Ramey, Katherine S Pollard, David A Prober, Jay Schulkin, Karl Deisseroth and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Deficiency in the cell-adhesion moleculeFrontiers in cell and developmental biology · 2023
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Mahendra WagleDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94143-2811, USA.ORCID http://orcid.org/0000-0003-1802-9330
Mahdi ZareiDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94143-2811, USA.
Matthew Lovett-BarronDepartment of Bioengineering, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Kristina Tyler PostonDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94143-2811, USA.
Jin XuTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Vince RameyBiophysics Graduate Group, University of California, Berkeley, CA, USA.
Katherine S PollardGladstone Institute of Data Science & Biotechnology, San Francisco, CA, USA.
David A ProberTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Jay SchulkinDepartment of Obstetrics & Gynecology, School of Medicine, University of Washington, Seattle, WA, USA.
Karl DeisserothDepartment of Bioengineering, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9440-3967
Su GuoDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94143-2811, USA. su.guo@ucsf.edu.ORCID http://orcid.org/0000-0002-7342-0108
University of California, San Francisco · USCalifornia Institute of Technology · USHoward Hughes Medical Institute · USGladstone Institutes · USInvitae (United States) · USUniversity of Washington · US

Funding

Genetic and Neuronal Mechanisms that Regulate Zebrafish Sleep - DIVERSITY SUPPLEMENTR35NS122172 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI David Aaron Prober · 2021 to 2026
$6.1M
Mechanisms that drive the variation of aversive behaviorR01GM132500 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUO, SU · 2019 to 2022
$2.5M
Discovery and characterization of brain-wide neuromodulatory circuits regulating arousalR00MH112840 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOVETT-BARRON, MATTHEW · 2020 to 2022
$746k
Discovery and characterization of brain-wide neuromodulatory circuits regulating arousalK99MH112840 · NIMH · STANFORD UNIVERSITY · PI LOVETT-BARRON, MATTHEW · 2017 to 2018
$242k
NIGMS NIH HHS R01 GM132500NIMH NIH HHS K99 MH112840NIMH NIH HHS R00 MH112840NINDS NIH HHS R35 NS122172
6 · The paper itself

Abstract

Salient sensory stimuli are perceived by the brain, which guides both the timing and outcome of behaviors in a context-dependent manner. Light is such a stimulus, which is used in treating mood disorders often associated with a dysregulated hypothalamic-pituitary-adrenal stress axis. Relationships between the emotional valence of light and the hypothalamus, and how they interact to exert brain-wide impacts remain unclear. Employing larval zebrafish with analogous hypothalamic systems to mammals, we show in free-swimming animals that hypothalamic corticotropin releasing factor (CRF

Indexed as

Corticotropin-Releasing HormoneParaventricular Hypothalamic NucleusAnimalsBrainCalciumHypothalamusMammalsNeuronsPerceptionZebrafishCalciumCorticotropin-Releasing Hormone

Identifiers

PMID35484242
PMCPMC9613822
OpenAlexW4224981795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.