ArticleCommunications biology2022
Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Open diffusion magnetic resonance imaging and connectivity data for epilepsy and surgery: The IDEAS II release.Epilepsia · 2026Article
- Brain network controllability in genetic risk, childhood abuse, and adult anxiety.European journal of psychotraumatology · 2025Article
- High energy consumption characterizes abnormal brain state transitions in temporal lobe epilepsy.Neurobiology of disease · 2025Article
- Individualized Frequency-Dependent Stimulation to the Anterior Nucleus of the Thalamus May Improve Antiepileptic Effects in Patients With Focal Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Network control theory uncovers aberrant connectome controllability in trigeminal neuralgia.The journal of headache and pain · 2025Article
- Longitudinal alterations in brain networks and thalamocortical connectivity in paediatric focal epilepsy: a structural connectomics pilot study.Brain communications · 2025Article
- Indirect structural changes and reduced controllability after temporal lobe epilepsy resection.Epilepsia · 2024Article
- Predicting seizure outcome after epilepsy surgery: Do we need more complex models, larger samples, or better data?Epilepsia · 2023Article
- Resolving inter-regional communication capacity in the human connectome.Network neuroscience (Cambridge, Mass.) · 2023Article
- Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022Review
- Structure-function models of temporal, spatial, and spectral characteristics of non-invasive whole brain functional imaging.Frontiers in neuroscience · 2022Review
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
Network control theory provides a framework by which neurophysiological dynamics of the brain can be modelled as a function of the structural connectome constructed from diffusion MRI. Average controllability describes the ability of a region to drive the brain to easy-to-reach neurophysiological states whilst modal controllability describes the ability of a region to drive the brain to difficult-to-reach states. In this study, we identify increases in mean average and modal controllability in children with drug-resistant epilepsy compared to healthy controls. Using simulations, we purport that these changes may be a result of increased thalamocortical connectivity. At the node level, we demonstrate decreased modal controllability in the thalamus and posterior cingulate regions. In those undergoing resective surgery, we also demonstrate increased modal controllability of the resected parcels, a finding specific to patients who were rendered seizure free following surgery. Changes in controllability are a manifestation of brain network dysfunction in epilepsy and may be a useful construct to understand the pathophysiology of this archetypical network disease. Understanding the mechanisms underlying these controllability changes may also facilitate the design of network-focussed interventions that seek to normalise network structure and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.