ArticleNature communications2022
Kidney epithelial cells are active mechano-biological fluid pumps.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026Review
- Photonic-crystal hydraulic manometry quantifies epithelial basal compression for rapid, label-free functional screening.Science advances · 2026Article
- Electrodiffusion active pump model with asymmetric immersed chemical potentials.bioRxiv : the preprint server for biology · 2026Article
- Cell-nanoplastics association impacts cell proliferation and motility.bioRxiv : the preprint server for biology · 2026Article
- Advances in mechanical force-induced adaptive responses and pathological transition of renal tubular epithelial cells.Frontiers in cell and developmental biology · 2026Review
- Regulation of epithelial tissue homeostasis by active transepithelial transport.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- 3D Printed Transwell Microfluidic Devices for Epithelial Cell Culture with Shear Stress.ACS measurement science au · 2025Article
- Voltage-gated ion channels in cultured gill epithelia of rainbow trout, Oncorhynchus mykiss, change in transcript abundance with exposure to freshwater.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Fluid and solute transport by cells and a model of systemic circulation.PLoS computational biology · 2025Article
- PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.Science advances · 2025Article
- Fluid transport comes to the fore.eLife · 2025Article
- Article
- High-Precision Micro-Total Analysis of Sodium Ions in Breast Milk.Sensors and actuators. B, Chemical · 2025Article
- Spatially defined microenvironment for engineering organoids.Biophysics reviews · 2024Review
- Cell-Driven Fluid Dynamics: A Physical Model of Active Systemic Circulation.bioRxiv : the preprint server for biology · 2024Article
- Advancements in therapeutic development: kidney organoids and organs on a chip.Kidney international · 2024Review
- Ultrafast universal fabrication of configurable porous silicone-based elastomers by Joule heating chemistry.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Precision nephrotoxicity testing using 3D in vitro models.Cell & bioscience · 2023Review
- Revolutionizing the female reproductive system research using microfluidic chip platform.Journal of nanobiotechnology · 2023Review
- Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
The role of mechanical forces driving kidney epithelial fluid transport and morphogenesis in kidney diseases is unclear. Here, using a microfluidic platform to recapitulate fluid transport activity of kidney cells, we report that renal epithelial cells can actively generate hydraulic pressure gradients across the epithelium. The fluidic flux declines with increasing hydraulic pressure until a stall pressure, in a manner similar to mechanical fluid pumps. For normal human kidney cells, the fluidic flux is from apical to basal, and the pressure is higher on the basal side. For human Autosomal Dominant Polycystic Kidney Disease cells, the fluidic flux is reversed from basal to apical. Molecular and proteomic studies reveal that renal epithelial cells are sensitive to hydraulic pressure gradients, changing gene expression profiles and spatial arrangements of ion exchangers and the cytoskeleton in different pressure conditions. These results implicate mechanical force and hydraulic pressure as important variables during kidney function and morphological change, and provide insights into pathophysiological mechanisms underlying the development and transduction of hydraulic pressure gradients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.