ArticleScientific reports2022
Feline herpesvirus infection and pathology in captive snow leopard.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Exposure to Feline Viruses in European Wildcats (Viruses · 2026Article
- Development of a Closed One-Tube Colorimetric and Fluorescent LAMP Assay for the Rapid Detection of Feline Herpesvirus 1.Animals : an open access journal from MDPI · 2026Article
- Host-specificity assessment of feline alphaherpesvirus-1 derived immunocontraceptive candidates in non-feline models.Virology journal · 2026Article
- Advances in the application of recombinant herpesvirus-vectored vaccines in animal disease control.Frontiers in microbiology · 2026Review
- Establishment of a loop-mediated isothermal amplification-lateral flow dipstick assay for the point-of-care testing of feline herpesvirus-1.Frontiers in veterinary science · 2026Article
- Evaluating triple inactivated vaccine-induced immunity from a large-scale study in feline population.Scientific reports · 2025Article
- Development and Validation of a Droplet Digital PCR Assay for Detection of Feline Herpesvirus Type-1.Veterinary sciences · 2025Article
- The Therapeutic Efficacy and Molecular Mechanisms ofVeterinary sciences · 2025Article
- Alphaherpesvirus in Pets and Livestock.Microorganisms · 2025Review
- Novel Strain-Based Triple Inactivated Vaccine Confers Rapid Neutralizing Immunity to Feline Multisystemic Pathogens With Two-Dose Regimen.Transboundary and emerging diseases · 2025Article
- Investigation of eye flora in cats infected with Herpesvirus and Calicivirus.Iranian journal of microbiology · 2024Article
- Identification, Genetic Characterization, and Pathogenicity of Three Feline Herpesvirus Type 1 Isolates from Domestic Cats in China.Veterinary sciences · 2024Article
- Novel Alpha-, Beta-, and Gammaherpesviruses in Neotropical Carnivores of Brazil.Transboundary and emerging diseases · 2024Article
- Occurrence of Typical Domestic Animal Viruses in Wild Carnivorans: An Emerging Threat to the Conservation of Endangered Species.Transboundary and emerging diseases · 2024Article
- Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine.Frontiers in veterinary science · 2024Article
- Pathogenicity and immunogenicity of gI/gE/TK-gene-deleted Felid herpesvirus 1 variants in cats.Virology journal · 2023Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feline herpesvirus type 1 (FHV-1) is a common causative agent of domestic cats' rhinotracheitis in domestic cats, and it increasingly threatens wild felids worldwide. The endangered snow leopard (Panthera uncia) belongs to the family Felidae, and it is the top predator on the Tibetan Plateau. Here we report the identification and isolation of FHV-1 from three dead captive snow leopards that presented with sneezing and rhinorrhea. To explore the relationship between FHV-1 and their deaths, organs and nasal swabs were collected for histopathology, viral isolation and sequence analysis. The results revealed that all three snow leopards were infected with FHV-1. The first animal died primarily of cerebral infarction and secondary non-suppurative meningoencephalitis that was probably caused by FHV-1. The second animal died mainly of renal failure accompanied by interstitial pneumonia caused by FHV-1. The cause of death for the third animal was likely related to the concurrent reactivation of a latent FHV-1 infection. The gD and gE gene sequence alignment of the isolated FHV-1 isolate strain revealed that the virus likely originated from a domestic cat. It was found that FHV-1 infection can cause different lesions in snow leopards than in domestic cats and is associated with high risk of disease in wild felids. This suggests that there should be increased focus on protecting wild felids against FHV-1 infections originating from domestic cats.
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