ArticleNature communications2022
ERK1/2 is an ancestral organising signal in spiral cleavage.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida.Nature communications · 2026Article
- Evidence of autonomous neural specification for both brain and ventral nerve cord tissue in Annelida.bioRxiv : the preprint server for biology · 2026Article
- A chromosome-level assembly and functional genomic resources for the model annelidbioRxiv : the preprint server for biology · 2025Article
- Cell fate specification modes shape transcriptome evolution in the highly conserved spiral cleavage.EMBO reports · 2025Article
- Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria.Genome biology · 2024Article
- The development of the adult nervous system in the annelid Owenia fusiformis.Neural development · 2024Article
- Embryonic organizer specification in the mud snail Ilyanassa obsoleta depends on intercellular signaling.Development (Cambridge, England) · 2023Article
- Single-cell transcriptomics refuels the exploration of spiralian biology.Briefings in functional genomics · 2023Review
- Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod molluskMarine life science & technology · 2023Article
- Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms.Nature communications · 2023Article
- Article
- Early mesodermal development in the patellogastropodEvolutionary applications · 2023Article
- The Fox Gene Repertoire in the Annelid Owenia fusiformis Reveals Multiple Expansions of the foxQ2 Class in Spiralia.Genome biology and evolution · 2022Article
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4 authors.
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Abstract
Animal development is classified as conditional or autonomous based on whether cell fates are specified through inductive signals or maternal determinants, respectively. Yet how these two major developmental modes evolved remains unclear. During spiral cleavage-a stereotypic embryogenesis ancestral to 15 invertebrate groups, including molluscs and annelids-most lineages specify cell fates conditionally, while some define the primary axial fates autonomously. To identify the mechanisms driving this change, we study Owenia fusiformis, an early-branching, conditional annelid. In Owenia, ERK1/2-mediated FGF receptor signalling specifies the endomesodermal progenitor. This cell likely acts as an organiser, inducing mesodermal and posterodorsal fates in neighbouring cells and repressing anteriorising signals. The organising role of ERK1/2 in Owenia is shared with molluscs, but not with autonomous annelids. Together, these findings suggest that conditional specification of an ERK1/2
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