Evidence map›Paper›PMID 35483965›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

CD133 as a Biomarker for an Autoantibody-to-ImmunoPET Paradigm for the Early Detection of Small Cell Lung Cancer.

Andrew G Kunihiro, Samantha M Sarrett, Kristin J Lastwika, Joell L Solan, Tatyana Pisarenko, Outi Keinänen, Cindy Rodriguez, Lydia R Taverne, Annette L Fitzpatrick, Christopher I Li and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Current and future therapies for small cell lung carcinoma.Journal of hematology & oncology · 2025
    Review
  4. Review
  5. Molecular Imaging of Cancer Stem Cells and Their Role in Therapy Resistance.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  6. Article
  7. Review
  8. EJNMMI research · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Radionuclide-based theranostics - a promising strategy for lung cancer.European journal of nuclear medicine and molecular imaging · 2023
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Andrew G KunihiroTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Samantha M SarrettDepartment of Chemistry, Hunter College, City University of New York, New York, New York.
Kristin J LastwikaTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Joell L SolanTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Tatyana PisarenkoClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Outi KeinänenDepartment of Chemistry, Hunter College, City University of New York, New York, New York.
Cindy RodriguezDepartment of Chemistry, Hunter College, City University of New York, New York, New York.
Lydia R TaverneTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Annette L FitzpatrickDepartment of Family Medicine, University of Washington, Seattle, Washington.
Christopher I LiTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
A McGarry HoughtonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Brian M ZeglisDepartment of Chemistry, Hunter College, City University of New York, New York, New York; bz102@hunter.cuny.edu plampe@fredhutch.org.
Paul D LampeTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; bz102@hunter.cuny.edu plampe@fredhutch.org.
Fred Hutch Cancer Center · USCity University of New York · USMemorial Sloan Kettering Cancer Center · USUniversity of Washington · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkersP50CA228944 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PHILIP D GREENBERG · 2019 to 2026
$19.6M
Fred Hutchinson Breast Cancer Clinical Validation CenterU01CA152637 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christopher I Li, Savannah Corrina Partridge · 2010 to 2026
$14.6M
NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
Chromosome Metabolism and Cancer Training GrantT32CA009657 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 1991 to 2020
$7.6M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
UW Post-Baccalaureate Research Education Program (PREP)R25GM086304 · NIGMS · UNIVERSITY OF WASHINGTON · PI Gabriele Varani · 2011 to 2026
$5.7M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
NCATS NIH HHS KL2 TR002317NCI NIH HHS F32 CA261055NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA228944NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS R01 CA243328NCI NIH HHS R01 CA244327NCI NIH HHS T32 CA009657NCI NIH HHS U01 CA152637NCI NIH HHS U01 CA185097NCI NIH HHS U01 CA186157NCI NIH HHS U01 CA221046NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIBIB NIH HHS R21 EB030275NIEHS NIH HHS K99 ES034053NIGMS NIH HHS R25 GM086304
6 · The paper itself

Abstract

Small cell lung cancer (SCLC) is a deadly neuroendocrine tumor for which there are no screening methods sensitive enough to facilitate early, effective intervention. We propose targeting the neuroendocrine tumor neoantigen CD133 via antibody-based early detection and PET (immunoPET) to facilitate earlier and more accurate detection of SCLC.

Indexed as

Lung NeoplasmsNeuroendocrine TumorsSmall Cell Lung CarcinomaAnimalsAutoantibodiesBiomarkersCell Line, TumorDisease Models, AnimalEarly Detection of CancerHumansMiceMice, NudePositron-Emission TomographyRNA, MessengerAutoantibodiesBiomarkersRNA, MessengerautoantibodyCD133immunoPETSCLC

Identifiers

PMID35483965
PMCPMC9635686
OpenAlexW4225156137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.