ArticleNature2022
Inflammasome activation in infected macrophages drives COVID-19 pathology.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed, 1 pooled it
50.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
348 citing papers in PubMed, 1 synthesis or guideline pooled it, 516 citations in OpenAlex.
- Cell-intrinsic and -extrinsic effects of SARS-CoV-2 RNA on pathogenesis: single-cell meta-analysis.mSphere · 2023Pooled it
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.Nature communications · 2024Trial
- Comparative innate immune responses across major RNA and DNA viral infections: Mechanisms, immunopathology, and therapeutic perspectives.Human vaccines & immunotherapeutics · 2026Review
- The gut-lung axis and viral pneumonia: Unrevealing the gut microbiota.Pharmaceutical science advances · 2026Review
- Caspase-11-mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection.JCI insight · 2026Article
- Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.Science advances · 2026Article
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.The Journal of clinical investigation · 2026Article
- Porcine coronavirus promotes NLRP3 inflammasome activation during virus-induced neuroinflammation.mBio · 2026Article
- Let-7a-5p/SHIP-1 Axis Drives SARS-CoV-2 Spike-1-Induced Microglial Pyroptosis.International journal of molecular sciences · 2026Article
- Vaccination-first immune priming shapes a sustained mRNA vaccine-induced IgG4 class switch that associates with SARS-CoV-2 breakthrough infection risk.Scientific reports · 2026Article
- SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages.Science advances · 2026Article
- Involvement of NLRP3 Inflammasome in Methamphetamine Augmentation of SARS-CoV-2 N-Protein-Induced Neuroinflammation in Rat Microglial Cells.International journal of molecular sciences · 2026Article
- Oxidative stress, antioxidant depletion, and DNA damage in post-COVID-19 patients: evidence of a disrupted redox network and loss of age-dependent antioxidant compensation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens.Nature microbiology · 2026Review
- Folic Acid and Endothelial Dysfunction in COVID-19.Life (Basel, Switzerland) · 2026Review
- DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity.bioRxiv : the preprint server for biology · 2026Article
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.bioRxiv : the preprint server for biology · 2026Article
- Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice.Journal of virology · 2026Article
- Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation.Nature communications · 2026Article
- Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.bioRxiv : the preprint server for biology · 2026Article
288 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
21 authors at 4 institutions in 2 countries.
Esen SefikDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-6807-3498
Rihao QuDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Caroline JunqueiraProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0545-0986
Eleanna KaffeDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Haris MirzaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Jun ZhaoDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
J Richard BrewerDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Ailin HanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Holly R SteachDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0018-3129
Benjamin IsraelowDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-1308-8246
Holly N BlackburnDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Sofia E VelazquezDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5954-3518
Y Grace ChenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3574-5734
Stephanie HaleneDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2737-9810
Akiko IwasakiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7824-9856
Eric MeffreDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-4326-0171
Michel NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0592-8564
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6200-4715
Craig B WilenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2495-9403
Yuval KlugerDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3035-071X
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Richard.Flavell@yale.edu.ORCID http://orcid.org/0000-0003-4461-0778
Yale University · USHoward Hughes Medical Institute · USBoston Children's Hospital · USYale Cancer Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0MRegulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MYale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7MTRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1MViral and immune-mediated CNS pathology during SARS-CoV-2 infectionR01AI157488 · NIAID · YALE UNIVERSITY · PI FARHADIAN, SHELLI, IWASAKI, AKIKO · 2020 to 2024
$4.7MThe role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9MImmuno-Serological Assays for Monitoring COVID19 in Patients with Hematologic MalignanciesU01CA260507 · NCI · YALE UNIVERSITY · PI FAN, RONG, HALENE, STEPHANIE · 2020 to 2024
$3.5MThe Regulation of Circular RNA FunctionsR35GM142687 · NIGMS · YALE UNIVERSITY · PI CHEN, YE GRACE · 2021 to 2025
$2.2MHuman Gut Commensal Cross-reactivity in Antiphospholipid SyndromeR01AI118855 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A., MEFFRE, ERIC · 2015 to 2019
$2.1MEFFICIENT METHODS FOR CALIBRATION, CLUSTERING, VISUALIZATION AND IMPUTATION OF LARGE scRNA-seq DATAR01GM131642 · NIGMS · YALE UNIVERSITY · PI KLUGER, YUVAL · 2019 to 2022
$1.6MRole of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940kHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NCI NIH HHS F30 CA239444NCI NIH HHS P30 CA016359NCI NIH HHS U01 CA260507NIAID NIH HHS K08 AI128043NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI118855NIAID NIH HHS R01 AI148467NIAID NIH HHS R01 AI157488NIAID NIH HHS T32 AI007517NIDDK NIH HHS U54 DK106857NIGMS NIH HHS R01 GM131642NIGMS NIH HHS R01 GM135928NIGMS NIH HHS R35 GM142687
Abstract
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for pathology in the SARS-CoV-2-infected MISTRG6-hACE2 humanized mouse model of COVID-19, which has a human immune system
Indexed as
COVID-19InflammasomesMacrophagesSARS-CoV-2Angiotensin-Converting Enzyme 2AnimalsHumansInterleukin-1Interleukin-18LungMiceNLR Family, Pyrin Domain-Containing 3 ProteinPneumoniaPyroptosisReceptors, IgGAngiotensin-Converting Enzyme 2InflammasomesInterleukin-1Interleukin-18NLR Family, Pyrin Domain-Containing 3 ProteinReceptors, IgG
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.