Evidence map›Paper›PMID 35483204›Full record

SynthesisEpilepsy & behavior : E&B2022

Movement disorders associated with antiseizure medications: A systematic review.

Daniel J Zhou, Spriha Pavuluri, Isha Snehal, Cynthia M Schmidt, Miguel Situ-Kcomt, Olga Taraschenko

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Epilepsy & behavior : E&B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Mild motor signs and depression: more than just medication side effects?European archives of psychiatry and clinical neuroscience · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Phenomenology of Tremor In 48,XXYY Syndrome: A Case Report.Movement disorders clinical practice · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel J ZhouDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Spriha PavuluriDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Isha SnehalDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Cynthia M SchmidtLeon S. McGoogan Health Sciences Library, University of Nebraska Medical Center, Omaha, NE, United States.
Miguel Situ-KcomtDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Olga TaraschenkoDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: olha.taraschenko@unmc.edu.
University of Nebraska Medical Center · US

Funding

Translational Imaging and Behavioral Assessment (TIBA) CoreP20GM130447 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Anna Dunaevsky · 2020 to 2026
$20.7M
NIGMS NIH HHS P20 GM130447
6 · The paper itself

Abstract

New-onset movement disorders have been frequently reported in association with the use of antiseizure medications (ASMs). The frequency of specific motor manifestations and the spectrum of their semiology for various ASMs have not been well characterized. We carried out a systematic review of literature and conducted a search on CINAHL, Cochrane Library, EMBASE, MEDLINE, PsycINFO, and Scopus from inception to April 2021. We compiled the data for all currently available ASMs using the conventional terminology of movement disorders. Among 5123 manuscripts identified by the search, 437 met the inclusion criteria. The largest number of reports of abnormal movements were in association with phenobarbital, valproic acid, lacosamide, and perampanel, and predominantly included tremor and ataxia. The majority of attempted interventions for all agents were discontinuation of the offending drug or dose reduction which led to the resolution of symptoms in most patients. Familiarity with the movement disorder phenomenology previously encountered in relation with specific ASMs facilitates early recognition of adverse effects and timely institution of targeted interventions.

Indexed as

AnticonvulsantsMovement DisordersHumansLacosamidePhenobarbitalValproic AcidAnticonvulsantsLacosamidePhenobarbitalValproic AcidAdverse effectsAntiseizure medicationsDrug-inducedMovement disorder

Identifiers

PMID35483204
PMCPMC9596228
OpenAlexW4224607717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.