Evidence map›Paper›PMID 35482975›Full record

ArticleJournal of the American Chemical Society2022

Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.

John A Roque Iii, Houston D Cole, Patrick C Barrett, Liubov M Lifshits, Rachel O Hodges, Susy Kim, Gagan Deep, Antonio Francés-Monerris, Marta E Alberto, Colin G Cameron and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
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  4. Review
  5. π-Extended Ru-COUBPY Photosensitizers forJournal of the American Chemical Society · 2025
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  10. Shift of cell-death mechanisms in primary human neutrophils with a ruthenium photosensitizer.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

John A Roque IiiDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, United States.
Houston D ColeDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, United States.
Patrick C BarrettDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Liubov M LifshitsDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, United States.
Rachel O HodgesDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Susy KimDepartment of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States.
Gagan DeepDepartment of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States.
Antonio Francés-MonerrisDepartament de Química Física, Universitat de València, Burjassot 46100, Spain.ORCID 0000-0001-8232-4989
Marta E AlbertoDipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, Arcavacata di Rende 87036, Italy.ORCID 0000-0001-9925-7233
Colin G CameronDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, United States.ORCID 0000-0003-0978-0894
Sherri A McFarlandDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, United States.ORCID 0000-0002-8028-5055
The University of Texas at Arlington · USUniversity of North Carolina at Greensboro · USWake Forest University · USUniversitat de València · ESUniversity of Calabria · IT

Funding

Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapyR01CA222227 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI GUJAR, SHASHI, MCFARLAND, SHERRI · 2018 to 2022
$2.6M
NCI NIH HHS R01 CA222227
6 · The paper itself

Abstract

Ru(II) complexes that undergo photosubstitution reactions from triplet metal-centered (

Indexed as

PhotochemotherapyRutheniumHumansHypoxiaPhenanthrolinesPhotosensitizing AgentsPhenanthrolinesPhotosensitizing AgentsRuthenium

Identifiers

PMID35482975
PMCPMC9098688
OpenAlexW4225160216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.