ArticleBlood2022
Intervening on the storage time of RBC units and its effects on adverse recipient outcomes using real-world data.
Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Quality improvement project for minimising red blood cell unit wastage at a secondary referral hospital in Malawi.BMJ open quality · 2026Article
- Vein-to-vein data: what predicts platelet response?Blood advances · 2026Article
- Design and Implementation of Observational Studies Emulating a Target Trial.JAMA network open · 2026Article
- Article
- Rapid oxygen release from stored red blood cells can be preserved for longer with refined additive solutions.Transfusion · 2025Article
- Irradiated red blood cell transfusion is associated with an increased incidence of deep vein thrombosis in trauma patients: a cohort study.BMC anesthesiology · 2025Article
- Engineered supercooling systems for enhanced long-term preservation of large-volume red blood cells in commercial blood bags.Journal of biological engineering · 2025Article
- Impacts of red blood cell suspension storage on pediatric outcomes: pediatric medicine and pediatric surgery.Translational pediatrics · 2025Article
- Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood.EBioMedicine · 2025Article
- Cost Reduction in Blood Transfusions After Implementation of Decision Protocol Based on Hemoglobin and Anemia Symptoms: A Pre-Post Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Effect of storage duration on outcome of patients receiving red blood cell in emergency department.Scientific reports · 2024Article
- Heavy metals in red blood cells: From "Iron Maiden" to "Lead" Zeppelin.Transfusion · 2024Article
- Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: History and scenario of patient blood management in the world and in Brazil.Hematology, transfusion and cell therapy · 2024Article
- Hypoxically stored RBC resuscitation in a rat model of traumatic brain injury and severe hemorrhagic shock.Life sciences · 2024Article
- Article
- Red Blood Cell Storage: From Genome to Exposome Towards Personalized Transfusion Medicine.Transfusion medicine reviews · 2023Review
- Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Review
- Omics Markers of Red Blood Cell Transfusion in Trauma.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Randomized controlled trials (RCTs) have found no evidence that the storage time of transfused red blood cell (RBC) units affects recipient survival. However, inherent difficulties in conducting RBC transfusion RCTs have prompted critique of their design, analyses, and interpretation. Here, we address these issues by emulating hypothetical randomized trials using large real-world data to further clarify the adverse effects of storage time. We estimated the comparative effect of transfusing exclusively older vs fresher RBC units on the primary outcome of death, and the secondary composite end point of thromboembolic events, or death, using inverse probability weighting. Thresholds were defined as 1, 2, 3, and 4 weeks of storage. A large Danish blood transfusion database from the period 2008 to 2018 comprising >900 000 transfusion events defined the observational data. A total of 89 799 patients receiving >340 000 RBC transfusions during 28 days of follow-up met the eligibility criteria. Treatment with RBC units exclusively fresher than 1, 2, 3, and 4 weeks of storage was found to decrease the 28-day recipient mortality with 2.44 percentage points (pp) (0.86 pp, 4.02 pp), 1.93 pp (0.85 pp, 3.02 pp), 1.06 pp (-0.20 pp, 2.33 pp), and -0.26 pp (-1.78 pp, 1.25 pp) compared with transfusing exclusively older RBC units, respectively. The 28-day risk differences for the composite end point were similar. This study suggests that transfusing exclusively older RBC units stored for >1 or 2 weeks increases the 28-day recipient mortality and risk of thromboembolism or death compared with transfusing fresher RBC units.
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