ArticleEvolution; international journal of organic evolution2022
Consequences of partially recessive deleterious genetic variation for the evolution of inversions suppressing recombination between sex chromosomes.
Article in Evolution; international journal of organic evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- A Chromosome Inversion Creates a Supergene for Sex and Colour in Lake Malawi Cichlids.Molecular ecology · 2025Article
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- Consequences of partially recessive deleterious genetic variation for the evolution of inversions suppressing recombination between sex chromosomes1.Evolution; international journal of organic evolution · 2024Article
- Turnover of sex chromosomes in the Lake Tanganyika cichlid tribe Tropheini (Teleostei: Cichlidae).Scientific reports · 2024Article
- Evolution of a plant sex chromosome driven by expanding pericentromeric recombination suppression.Scientific reports · 2024Article
- The evolutionary maintenance of ancient recombining sex chromosomes in the ostrich.PLoS genetics · 2023Article
- Heterochiasmy and Sex Chromosome Evolution inGenes · 2023Article
- Slower-X: reduced efficiency of selection in the early stages of X chromosome evolution.Evolution letters · 2023Article
- Independent Evolution of Sex Chromosomes and Male Pregnancy-Related Genes in Two Seahorse Species.Molecular biology and evolution · 2023Article
- Recent expansion of the non-recombining sex-linked region on Silene latifolia sex chromosomes.Journal of evolutionary biology · 2022Article
- Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes.PLoS biology · 2022Article
- Consequences of partially recessive deleterious genetic variation for the evolution of inversions suppressing recombination between sex chromosomes.Evolution; international journal of organic evolution · 2022Article
Corrections and comments
- Expression of concern · 2023-06-03Error in Analyses · Updated to Retraction · · see: https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpae060/7689181
- Retraction · 2024-06-10Error in Analyses · Error in Results and/or Conclusions · Retract and Replace · Upgrade/Update of Prior Notice(s) · · see: https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpae060/7689181
- Expression of concern
- Republished as
- Retracted
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of suppressed recombination between sex chromosomes is widely hypothesized to be driven by sexually antagonistic selection (SA), where tighter linkage between the sex-determining gene(s) and nearby SA loci is favored when it couples male-beneficial alleles to the proto-Y chromosome, and female-beneficial alleles to the proto-X. Despite limited empirical evidence, the SA selection hypothesis overshadows several alternatives, including an incomplete but often-repeated "sheltering hypothesis" that suggests that expansion of the sex-linked region (SLR) reduces homozygous expression of partially recessive deleterious mutations at selected loci. Here, we use population genetic models to evaluate the consequences of deleterious mutational variation for the evolution of neutral chromosomal inversions expanding the SLR on proto-Y chromosomes. We find that SLR-expanding inversions face a race against time: lightly loaded inversions are initially beneficial, but eventually become deleterious as they accumulate new mutations, and must fix before this window of opportunity closes. The outcome of this race is strongly influenced by inversion size, the mutation rate, and the dominance coefficient of deleterious mutations. Yet, small inversions have elevated fixation probabilities relative to neutral expectations for biologically plausible parameter values. Our results demonstrate that deleterious genetic variation can plausibly drive recombination suppression in small steps and would be most consistent with empirical patterns of small evolutionary strata or gradual recombination arrest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.