Evidence map›Paper›PMID 35482655›Full record

SynthesisPloS one2022

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.

Petros C Dinas, Eleni Nintou, Maria Vliora, Anna E Pravednikova, Paraskevi Sakellariou, Agata Witkowicz, Zaur M Kachaev, Victor V Kerchev, Svetlana N Larina, James Cotton and 19 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 10 institutions in 5 countries.

Petros C DinasFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Eleni NintouFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Maria VlioraFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.ORCID 0000-0002-1884-1057
Anna E PravednikovaLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-4572-5318
Paraskevi SakellariouFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Agata WitkowiczL. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.ORCID 0000-0002-9696-5266
Zaur M KachaevLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Victor V KerchevLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Svetlana N LarinaLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
James CottonRoyal Wolverhampton NHS Trust, New Cross Hospital, Wolverhampton, United Kingdom.
Anna KowalskaInstitute of Human Genetics, Polish Academy of Sciences, Poznań, Poland.
Paraskevi GkiataFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Alexandra BargiotaDepartment of Endocrinology and Metabolic Diseases, Medical School, Larissa University Hospital, University of Thessaly, Larissa, Greece.
Zaruhi A KhachatryanInstitute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
Anahit A HovhannisyanInstitute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
Mariya A AntonosyanInstitute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
Sona MargaryanInstitute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
Anna PartykaL. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Pawel BogdanskiDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Poznań, Poland.
Monika SzulinskaDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Poznań, Poland.
Matylda Kregielska-NaroznaDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Poznań, Poland.
Rafał CzepczyńskiDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland.
Marek RuchałaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland.
Anna TomkiewiczL. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Levon YepiskoposyanDepartment of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian University, Yerevan, Armenia.
Lidia KarabonL. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Yulii ShidlovskiiLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-3643-9889
George S MetsiosDepartment of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
Andreas D FlourisFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.ORCID 0000-0002-9823-3915
University of Thessaly · GRPoznan University of Medical Sciences · PLInstitute of Molecular Biology · AMLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLSechenov University · RUInstitute of Gene Biology · RUInstitute of Human Genetics · PLNew Cross Hospital · GBRussian-Armenian University · AMUniversity of Wolverhampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contribution of UCP1 single nucleotide polymorphisms (SNPs) to susceptibility for cardiometabolic pathologies (CMP) and their involvement in specific risk factors for these conditions varies across populations. We tested whether UCP1 SNPs A-3826G, A-1766G, Ala64Thr and A-112C are associated with common CMP and their risk factors across Armenia, Greece, Poland, Russia and United Kingdom. This case-control study included genotyping of these SNPs, from 2,283 Caucasians. Results were extended via systematic review and meta-analysis. In Armenia, GA genotype and A allele of Ala64Thr displayed ~2-fold higher risk for CMP compared to GG genotype and G allele, respectively (p<0.05). In Greece, A allele of Ala64Thr decreased risk of CMP by 39%. Healthy individuals with A-3826G GG genotype and carriers of mutant allele of A-112C and Ala64Thr had higher body mass index compared to those carrying other alleles. In healthy Polish, higher waist-to-hip ratio (WHR) was observed in heterozygotes A-3826G compared to AA homozygotes. Heterozygosity of A-112C and Ala64Thr SNPs was related to lower WHR in CMP individuals compared to wild type homozygotes (p<0.05). Meta-analysis showed no statistically significant odds-ratios across our SNPs (p>0.05). Concluding, the studied SNPs could be associated with the most common CMP and their risk factors in some populations.

Indexed as

Cardiovascular DiseasesMetabolic DiseasesPolymorphism, Single NucleotideUncoupling Protein 1Case-Control StudiesCytidine MonophosphateGenetic Predisposition to DiseaseHumansPrevalenceCytidine MonophosphateUncoupling Protein 1

Identifiers

PMID35482655
PMCPMC9049362
OpenAlexW4226220100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.