ArticlePain medicine (Malden, Mass.)2022
Changes in Opioid Dispensing by Medical Specialties After the Release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain.
Article in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Cost-effective interventions to prevent prescription drug misuse: a systematic review.Frontiers in public health · 2025Pooled it
- CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2022Guideline
- Effectiveness of motivational interviewing plus cognitive behavioral therapy vs shared decision making for voluntary opioid tapering in patients with chronic pain: the INSPIRE randomized pragmatic trial.Pain medicine (Malden, Mass.) · 2025Trial
- A qualitative analysis on the implementation of a nudge intervention to reduce post-surgical opioid prescribing.BMC health services research · 2025Trial
- Short-Term and Long-Term Opioid Prescribing by Specialty, 2010 to 2024.JAMA network open · 2026Article
- Chronic Pain and Distress in the Primary Care Setting: Implementing a Digital Pain and Distress Screener to Optimize Integrated Psychological Treatment.Journal of clinical psychology in medical settings · 2026Article
- Primary care provider attitudes regarding physical therapists addressing opioid use and opioid misuse: a qualitative study.Physical therapy · 2026Article
- The impact of opioid prescribing guidelines on opioid dispensation: A systematic review and meta-analysis.Canadian journal of pain = Revue canadienne de la douleur · 2026Review
- Knowledge, attitudes and practices of pain management among Taiwanese physicians in a reformed 2-year postgraduate training programme: a cross-sectional questionnaire survey.Annals of medicine · 2025Article
- A panel management approach using prescription drug monitoring program data for primary care patients with chronic pain treated with opioids: a feasibility study.BMC primary care · 2025Article
- A Panel Management Approach Using Prescription Drug Monitoring Program Data for Primary Care Patients with Chronic Pain Treated with Opioids: A Feasibility Study.Research square · 2025Article
- The burden of acute pain in the U.S. in the wake of the opioid crisis.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Postoperative Opioid Consumption After Discharge: An Update From the Michigan Surgical Quality Collaborative Registry.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients.Drug and alcohol dependence · 2024Article
- Surgeons' views of peer comparison and guideline-based feedback on postsurgery opioid prescriptions: a qualitative investigation.BMJ open quality · 2024Article
- Opioid prescriptions among the World Trade Center Health Program population.BMC health services research · 2023Article
- Opioid Prescribing for Chronic Musculoskeletal Conditions: Trends over Time and Implementation of Safe Opioid-Prescribing Practices.Applied clinical informatics · 2023Article
- State-to-State Variation in Opioid Dispensing Changes Following the Release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain.JAMA network open · 2023Article
- Opioid versus non-opioid postoperative pain management in otolaryngology.BMC anesthesiology · 2023Article
- A retrospective analysis of pain changes and opioid use patterns temporally associated with a course of chiropractic care at a publicly funded inner-city facility.The Journal of the Canadian Chiropractic Association · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo identify changes in opioid prescribing across a diverse array of medical specialties after the release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain.
designInterrupted time-series analysis of data from a commercial prescribing database. SUBJECTS: De-identified recipients of opioid prescriptions dispensed at U.S. retail pharmacies between 2015 and 2019.
methodsOpioid dispensing data were obtained from the IQVIA Longitudinal Prescription (LRx) database, representing more than 800 million opioid prescriptions. Monthly dispensing rates, dosage in morphine milligram equivalents (MME), and mean prescription duration were calculated across 29 medical specialties. Changes in dispensing after the release of the 2016 CDC Guideline were assessed through interrupted time-series analysis.
resultsDeclining trends in opioid dispensing accelerated in 24 of 29 specialty groups after the release of the CDC Guideline (P < 0.05 for 15 groups). Decreases were greatest among family medicine clinicians, where declines accelerated by 4.4 prescriptions per month per 100,000 persons (P = 0.005), and surgeons, where declines accelerated by 3.6 prescriptions per month per 100,000 (P = 0.003).
conclusionsThese results illustrate that clinicians likely to provide primary care exhibited the greatest decreases in opioid dispensing. However, specialties outside the scope of the CDC Guideline (e.g., surgery) also exhibited accelerated decreases in prescribing. These declines illustrate that specialties beyond primary care could have interest in evaluating opioid prescribing practices, supporting the importance of specialty-specific guidance that balances the individualized risks and benefits of opioids and the role of non-opioid treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.