Evidence map›Paper›PMID 35482327›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Cross-bridge thermodynamics in pulmonary arterial hypertensive right-ventricular failure.

Toan Pham, Kenneth Tran, Andrew J Taberner, Denis S Loiselle, June-Chiew Han

Open access · hybridAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Toan PhamAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-6323-9217
Kenneth TranAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8651-3557
Andrew J TabernerAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Denis S LoiselleAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-6928-4019
June-Chiew HanAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-6396-7628
University of Auckland · NZ

Funding

Manatu Hauora | Health Research Council of New Zealand (HRC) 20/011Manatu Hauora | Health Research Council of New Zealand (HRC) 21/116Manatu Hauora | Health Research Council of New Zealand (HRC) 21/653National Heart Foundation of New Zealand 1692National Heart Foundation of New Zealand 1869Royal Society of New Zealand | Marsden Fund (Royal Society of New Zealand Marsden Fund) 1504Royal Society of New Zealand | Marsden Fund (Royal Society of New Zealand Marsden Fund) 1703Royal Society Te Apārangi (Royal Society of New Zealand) UOA1902
6 · The paper itself

Abstract

Right-ventricular (RV) failure is an event consequent to pathological RV hypertrophy commonly resulting from pulmonary arterial hypertension. This pathology is well characterized by RV diastolic dysfunction, impaired ejection, and reduced mechanical efficiency. However, whether the dynamic stiffness and cross-bridge thermodynamics in the failing RV muscles are compromised remains uncertain. Pulmonary arterial hypertension was induced in the rat by injection of monocrotaline, and RV trabeculae were isolated from RV failing rats. Cross-bridge mechano-energetics were characterized by subjecting the trabeculae to two interventions:

Indexed as

Heart FailureHypertension, PulmonaryPulmonary Arterial HypertensionVentricular Dysfunction, RightAnimalsPulmonary ArteryRatsRats, WistarThermodynamicsVentricular Function, Rightcardiac trabeculaecross-bridge thermodynamicsdynamic stiffnessmechano-energeticsright-ventricular failure

Identifiers

PMID35482327
PMCPMC9208464
OpenAlexW4225090170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.